Ion Mobility in Omics Applications

See more of what is really in your sample

Take a more in-depth look at how Waters’ Triwave Ion Mobility technology can help you see more of what is really in your sample with SYNAPT G2-Si High Definition MS System.

We have assembled an array of documents, webcasts and references to illustrate how TriWave can dramatically improve your ability to characterize complex mixtures and molecules in your applications.

Late breaking publications in the International Journal for Ion Mobility T-Wave IMS Special Editions

• Volume I
• Volume II

Peptides

• Resolving Chimeric Spectra Utilizing a Data Independent Mobility Acquisition Strategy
  Remove matrix/isobaric interferences, generate cleaner spectra - Technical Brief
• Resolving the Complexity of Proteomic Samples with Ion Mobility-Mass Spectrometry
  Increase peak capacity, increase identifications, remove matrix/isobaric interferences, generate cleaner spectra - Webinar Presentation
• Enhancing Accuracy and Depth-of-Coverage of Isotopically Labeled Samples Using Precursor and Product Ion Responses from Data Independent Analyzes (DIA)
  Remove matrix/isobaric interferences, generate cleaner spectra - Scientific Poster
• Using Ion Purity Scores For Enhancing Quantitative Accuracy And Precision In Complex Proteomics Samples
  Remove matrix/isobaric interferences, generate cleaner spectra, more identifications - Peer Reviewed Paper

Imaging

• Unparalleled Specificity Using HDMS Technology in a MALDI Imaging Experiment
  Remove matrix/isobaric interferences, generate cleaner spectra - Technology Brief
• A Drug and Metabolite Study in Whole Body Animal by High Definition MALDI Imaging
  Remove matrix/isobaric interferences, generate cleaner spectra - Scientific Poster
• High-Definition MALDI MS Imaging: Full Integration of the Ion Mobility Dimension from Acquisition to Visualization
  Remove matrix/isobaric interferences, generate cleaner spectra - Webinar Presentation

Metabolites, Lipids

• Incorporating Ion Mobility to Enhance Lipid Biomarker Profiling
  Increase peak capacity, increase identifications, remove matrix/isobaric interferences, generate cleaner spectra - Technology Brief
• Lipid Profiling of Serum Samples From Calcific Coronary Artery Disease Patients Using UPLC/TOF-HDMS^E and Multivariate Data Analysis
  Remove matrix/isobaric interferences, generate cleaner spectra - Scientific Poster
• Real Time Lipidomic Profiling Using Desorption Ionization with Ion Mobility Separation
  Increase peak capacity, Remove matrix/isobaric interferences, generate cleaner spectra - Scientific Poster

Biomarkers, Integrated Omics

• Qualitative and Quantitative Characterization of the Metabolome, Lipidome, and Proteome of Human Hepatocytes Stably Transfected with Cytochrome P450 2E1 Using Data Indepdendent LC/MS
  Increase peak capacity, Remove matrix/isobaric interferences, generate cleaner spectra - Application Note

Proteins, Peptides

• Advances in Electron Transfer Dissociation (ETD) on an Ion Mobility Enabled QTof Mass Spectrometer
  Separate isomers, generate cleaner spectra - Scientific Poster
• Differentiating Carbohydrate Structural And Positional Isomers By Ion-Mobility Mass Spectrometry
  Separate isomers, generate cleaner spectra - Scientific Poster
• Epitope Mapping through Automated Analysis of Hydrogen Deuterium Exchange Mass Spectrometry Data Using DynamiX
  Increased peak capacity, remove matrix/isobaric interferences, generate cleaner spectra - Scientific Poster
• Improved Ion Mobility Separation of Protein Conformations in the Gas Phase with SYNAPT G2 HDMS
  Separating conformers, characterize with cross section measurements - Application Note
• Evidence for macromolecular protein rings in the absence of bulk water
  Separating conformers, characterize with cross section measurements - Peer Reviewed Paper

Small Molecules

• Sites of metabolic substitution: investigating metabolite structures utilising ion mobility and molecular modelling
  Characterization with cross section measurements - Peer Reviewed Paper
• Product ion mobility as a promising tool for assignment of positional isomers of drug metabolites
  Characterization with cross section measurements, more complete fragmentation and characterization - Webinar Presentation
• Traditional Herbal Medicine Structural Elucidation using SYNAPT HDMS with Time-Aligned Parallel (TAP) Fragmentation
  More complete fragmentation and characterization - Application Note
• Collision Cross-Section Determination of Lipids on the MALDI SYNAPT G2 HDMS System
  Characterization with cross section measurements - Application Note
• Localization of fatty acyl and double bond positions in phosphatidylcholines using a dual stage CID fragmentation coupled with ion mobility mass spectrometry
  More complete fragmentation and characterization - Peer Reviewed Paper
• Ion mobility spectrometry-mass spectrometry (IMS-MS) of small molecules: Separating and assigning structures to ions
  Separate isomers, increase peak capacity, removal of interferences, generate cleaner spectra, characterization with cross section measurements - Peer Reviewed Paper