Ion Mobility in Pharma R&D Applications

See more of what is really in your sample

Take a more in-depth look at how Waters’ Triwave Ion Mobility technology can help you see more of what is really in your sample with SYNAPT G2-Si High Definition MS System.

We have assembled an array of documents, webcasts and references to illustrate how TriWave can dramatically improve your ability to characterize complex mixtures and molecules in your applications.

Late breaking publications in the International Journal for Ion Mobility T-Wave IMS Special Editions

• Volume I
• Volume II

Biopharmaceuticals - IMS-enhancement of Biotherapeutic Conformational Analysis

• Resolving Disulfide Structural Isoforms of IgG2 Monoclonal Antibodies by Ion Mobility Mass Spectrometry
  Separating conformers, characterize with cross section measurements - Peer Reviewed Paper
• Ion mobility adds an additional dimension to mass spectrometric analysis of solution-phase hydrogen/deuterium exchange
  Increased peak capacity, increase identifications, remove matrix/isobaric interferences, generate cleaner spectra - Peer Reviewed Paper
• Improved Ion Mobility Separation of Protein Conformations in the Gas Phase with SYNAPT G2 HDMS
  Separating conformers, characterize with cross section measurements - Application Note
• Travelling wave ion mobility mass spectrometry studies of protein structure: biological significance and comparison with X-ray crystallography and nuclear magnetic resonance spectroscopy measurements
  Separating conformers, characterize with cross section measurements - Peer Reviewed Paper
• Characterizing High-Order Structures of Therapeutic Proteins by Electrospray Ion-Mobility MS
  Separating conformers, characterize with cross section measurements - Scientific Poster

Biopharmaceuticals - IMS-enhancement of Biotherapeutic Characterization

• Characterization of simple isomeric oligosaccharides and the rapid separation of glycan mixtures by ion mobility mass spectrometry
  Separate isomers, generate cleaner spectra, increased peak capacity, remove isobaric/matrix interferences - Peer Reviewed Paper
• Gas-Phase Proton-Transfer Chemistry Coupled with TOF Mass Spectrometry and Ion Mobility-MS for the Facile Analysis of Poly(ethylene glycols) and PEGylated Polypeptide Conjugates
  Separate isomers, generate cleaner spectra, increased peak capacity, remove isobaric/matrix interferences - Peer Reviewed Paper
• Improving the Quality of Rapid LCMS Peptide Mapping Analyses for Biotherapeutic Proteins with Multiplexed Fragmentation and Ion Mobility Separations
  Increased peak capacity, generate cleaner spectra, remove isobaric/matrix interferences - Scientific Poster
• Differentiating Carbohydrate Structural And Positional Isomers By Ion-Mobility Mass Spectrometry
  Separate isomers, generate cleaner spectra - Scientific Poster
• Electrospray Ionisation Quadrupole Ion-mobility Time of Flight Mass Spectrometry as a Tool to Distinguish the lot-to-lot Heterogeneity in N-Glycosylation Profile of the Therapeutic Monoclonal Antibody Trastuzumab
  More complete fragmentation and characterization, Remove isobaric/matrix interferences - Peer Reviewed Paper

Small Molecules

• Use of High-Resolution QTOF With Enhanced Ion Mobility Capabilities for Facile Metabolite Identification and Characterization Using UPLC/IMS/MS(E)
  Remove matrix/isobaric interferences, generate cleaner spectra - Poster Presentation
• Evaluating the utility of ion mobility separation in combination with high-pressure liquid chromatography/mass spectrometry to facilitate detection of trace impurities in formulated drug products.
  Remove matrix/isobaric interferences, generate cleaner spectra, more identifications - Peer Reviewed Paper
• Unparalleled Specificity Using HDMS Technology in a MALDI Imaging Experiment
  Remove matrix/isobaric interferences, generate cleaner spectra - Technology Brief
• An Drug and Metabolite Study in Whole Body Animal by High Definition MALDI Imaging
  Remove matrix/isobaric interferences, generate cleaner spectra - Scientific Poster
• Structural Characterization of Drug-like Compounds by Ion Mobility Mass Spectrometry: Comparison of Theoretical and Experimentally Derived Nitrogen Collision Cross Sections
  Isomer separation - Peer Reviewed Paper
• Sites of metabolic substitution: investigating metabolite structures utilising ion mobility and molecular modelling
  Characterization with cross section measurements - Peer Reviewed Paper
• Product ion mobility as a promising tool for assignment of positional isomers of drug metabolites
  Characterization with cross section measurements, more complete fragmentation and characterization - Webinar Presentation
• Structural Elucidation using SYNAPT HDMS with Time-Aligned Parallel (TAP) Fragmentation
  More complete fragmentation and characterization - Application Note
• Ion mobility spectrometry-mass spectrometry (IMS-MS) of small molecules: Separating and assigning structures to ions
  Separate isomers, increase peak capacity, removal of interferences, generate cleaner spectra, characterization with cross section measurements - Peer Reviewed Paper