LC-MS/MS經常用於毒理學實驗室內，以進行濫用藥物之確認及定量應用。LC-MS/MS 一般被認知用於初篩化驗(如免疫法分析)後之確認分析。

近年來，在更多一般性未知化合物的篩選上均可見到LC-MS(MS)應用的增加，用於偵測或排除已知樣品中各種不同的物質（可能具有毒性的物質）。

「系統化毒理學分析」(STA)的全面策略，目標在於偵測樣品內（真實）所有相關的毒性物質，而Waters可提供您必要的解決方案，在此過程上為您的實驗室提供一臂之力。

Waters已開發新的MassTrak™臨床解決方案，可協助您的實驗室辨識樣品內的未知化合物。

這些MassTrak臨床解決方案對於未知化合物的辨識運用兩種不同且互補的辦法：

• 以UPLC-MS進行系統化毒理學分析
• 以UPLC-MS/MS進行標的MRM（多重反應監測）

對於這些解決方案及需提供準確且快速結果的實驗室而言，UPLC/MS為理想的技術。這些篩選解決方案可提供不同的分析方法，此方法單獨使用時極具多樣性，而組合使用時，則可提供您一種完善的方式辨識未知化合物。

這些MassTrak™ 毒理學解決方案可讓您：

• 易於操作
• 有彈性的工作措施
• 相關的化合物資料庫（可由使用者增加資料）
• 已通過Waters臨床應用專業人員驗證的方法
  

Underpinning our customers successes are Waters Services and Support initiatives which are designed specifically for clinical laboratories looking for performance optimization and the reassurance that they can get on-site support if an issue should arise. Waters provides priority on-site services, repairs, telephone support, and offers optional remote monitoring and diagnostic capabilities minimizing any downtime and optimizing your investment. Waters is committed to the results you gain from our integrated system solutions.

As such, the program sets new standards for MassTrak™ Systems support in your clinical laboratory.

• Guaranteed prioritized service
• Guaranteed two-hour response for callback after receipt of a support call
• Guaranteed on-site response time of two business days (48 hours)
• Single vendor support for HPLC and mass spectrometry systems and applications

The utilization of LC/MS (and particularly LC-MS/MS) in forensic toxicology laboratories has increased significantly in recent years. The sensitivity, rapid analysis, selectivity and simple sample pretreatment requirements have led to LC-MS/MS methods being adopted as the first choice for many important drugs of abuse analysis applications.

LC-MS/MS is particularly useful for:

• Polar, non-volatile and thermally labile compounds
• Compounds which are difficult to analyze by gas chromatography
• High-throughput laboratories
• Providing rapid results

With LC-MS/MS, most drugs can be analyzed without extensive sample pre-treatment or derivatization.

The sensitivity of LC-MS/MS also allows the use of volume-limited samples from alternative matrices e.g., hair, sweat and oral fluid.