|
When developing new medicines, pharmaceutical companies, contract research organisations (CROs) and academic laboratories need to quantify exactly how much of a drug or its metabolites are present in the fluid or tissue of a biological system.
Required at the discovery phase, through pre-clinical testing and during clinical trials, Xevo mass spectrometry systems allow you to create high-throughput and customizable testing environments. Multiple, robust instruments can be employed to ensure maximum reliability and backup options, while minimising downtime. Unlike alternative quantitation methods, MS allows many different analytes to be measured in each sample and a single platform to be used across many stages of development, for small and large molecule analysis.
Waters Xevo Mass Spectrometry Solutions Integrate:
- Chromatographic systems and mass spectrometers that combine accurate reproducible separations and maximum MS performance with intelligent, easy-to-use laboratory software converting scientific data into useful information.
- Chemistry consumables that work with your system to maximize sensitivity, increase throughput, and ensure the development of robust methods.
- Waters Applications Support and Global Services partner with you to optimize your laboratory efficiency, help maintain system peak performance, address scientific application challenges and meet your compliance requirements to ensure the success of your laboratory and business.
|
 |
To address the increasing need for higher sensitivity, the ionKey/MS system integrates the separation into the source of the mass spectrometer to provide a user-friendly single analysis platform. Through enhanced ionization efficiency and reduced matrix interference, the ionKey/MS System produces significant signal enhancements compared to analytical scale LC.
The Xevo G2-XS QTof delivers enhanced mass resolution and sensitivity through a collision cell design that improves ion focusing and reduces losses in ion transfer through the cell. In addition to new hardware, innovative software, and acquisition methods were also introduced to enable simple Tof-MRM modes of operation targeted for routine bioanalytical work.
The ionKey/MS system with the Xevo G2-XS QTof offers an ideal platform to meet modern challenges of both quantitative and qualitative analysis in pharmaceutical analysis, providing the user with flexibility and more confidence in their data.
|
 |
The sensitivity gains observed when using microflow LC-MS do not always translate into an everyday workflow advantage in a high throughput laboratory. The longer run times that are typical on a microflow scale deliver improved sensitivity, but decreased sample throughput when compared to UPLC. The ability to deliver high sensitivity at run times under 3 minutes compelled the need to develop a microflow device that can function on a UPLC timescale (<3 min).
This white paper introduces a novel microfluidic device capable of higher pressures and flow rates which enable run times under 3 minutes while still delivering improved sensitivity over traditional UPLC systems.
|
