代謝體學研究可使實驗室大幅加速新藥物的開發。比較及對照大型樣品群組的能力，可讓您洞悉當生物系統暴露於新的化學實體(NCE)時所發生的生化變化；而代謝體學可提供您偵測這些變化的快速、可靠方法，改善您對於潛在毒性的暸解，並可供您監控這些NCE的療效。代謝體學及代謝學資訊的正確執行，可協助生物科技及化學工業公司類似的發現、開發及製造過程；有了這些研究，科學家更能可以視覺化及鑑定樣品組合內的基本差異。

Waters UPLC^®/MS 系統結合UPLC分析、高解析度精確的質量MS、以及專業應用管理器的效益，可快速產生並解析資訊豐富的資料，因此可讓您快速做出有根據的決策。

結合ACQUITY UPC^® 系統、Synapt™ HDMS™、MarkerLynx 應用管理器並使用SIMCA-P強化其效能的情況下，可為您提供代謝體學研究方面的完善解決方案：

• HDMS可提供離子移動解析離額外的維度，強化的片段及MS^E 擷取
• UPLC及LCT Premier™ XE 為精確質量代謝體學篩選系統的替代解決方案
• MarkerLynx可提供完善的代謝體學資料處理能力，現在更以完全整合的SIMCA-P統計分析能力及MassFragment™結構解析軟體進行強化。

MarkerLynx應用管理器

針對代謝體學及代謝學使用UPLC^®/MS及GC/MS資料，包括四大關鍵步驟：波峰的偵測、波峰值的積分、波峰校正及統計分析。MarkerLynx 應用管理器使用多變數統計及先進且全面的資料庫整合，用以比較及鑑別數據組合來處理這些步驟。

MarkerLynx 畫面

MarkerLynx 與SIMCA-P間直接整合，可提供小分子分析研究中複雜數據集的全方位知識。

Metabonomics samples contain a chemically diverse range of compounds with a wide concentration range -all of which need to be measured accurately.

To complement the narrow peaks generated by the ACQUITY UPLC^® System, the LCT Premier^TM XE Mass Spectrometer provides rapid detection and identification of components in complex mixtures.

To facilitate the multivariate statistical approach that is essential to metabonomics analysis, a linear response from the detector is required to ensure high quality results. The LCT Premier XE delivers up to four orders-of-magnitude exact mass data, for reliable quantitative information.

UPLC/MS Metabonomics Applications

• Potential biomarker screening
• Toxicity screening
• Monitoring food quality
• Industrial production evaluation
• Academic medicinal chemistry research
• Agricultural process analysis

High-quality metabolic screening with GC/MS For metabolomics applications, capillary GC coupled to time-of-flight mass spectrometry is simple to use and provides highly sensitive analyses. This technique is ideally suited for the volatile, highly polar compounds often encountered in complex agricultural and industrial samples.

The GCT Premier^TM Mass Spectrometer is a powerful oa-TOF GC/MS system offering fast acquisition of full spectrum data, with high sensitivity and extended dynamic range. Exact mass capability facilitates elemental composition determination, offering a significant advantage over traditional GC/MS. The high full-scan sensitivity further extends its capability to profiling complex chromatograms.

GC /MS Metabolomics Applications

• Analysis of genetic strains in agriculture
• Fingerprinting of cosmetics
• Identification of biomarkers of disease
• Natural products analysis