當實驗室試圖找尋改善方法、並能充分發揮分析時間時，仍持續面對許多的挑戰：

• 在實驗室內，您是否正準備從樣品製備至報告結果上，尋求更簡單的工作流程？
• 您是否關切使用LC-MS/MS系統將會臨困難或耗費時間？

我們暸解，對於毒理學實驗室而言，可靠的數據資料及再現性都極具挑戰性。樣品製備、方法開發、結果解析及技術挑戰，都可能讓你無法取得正確的答案。

而Waters已開發完善的解決方案組合，包括針對毒理學及法醫實驗室所特別設計的儀器組合及應用。

我們在領先實驗室之毒理學解決方案安裝上的廣泛經驗，讓我們可以支援您廣泛而多樣化的相關應用注意事項，以及多年的應用開發經驗。

Waters 已結合UPLC無與倫比的層析解析度及質譜分析的選擇性與靈敏度，可讓實驗室在幾分鐘內即可從複雜的基質中辨識化合物並予以定量。

Waters UPLC-MS/MS解決方案包括功能強大的解析軟體、化學、專職的應用及支援服務，可擴充您的分析能力及工作流程。

液相層析串聯質譜分析(LC/MS/MS)為目前廣泛用於法醫毒理學實驗室內進行確認分析的技術。此項技能對於不易由氣相層析(GC)分析的極性、非揮發、熱不穩定化合物尤其有用。此外，相較於GC/MS，減少其樣品前處理及較短的LC/MS/MS分析時間，對於高樣品通量實驗室及需提供快速結果的實驗室，此技術更具有吸引力。

一旦具備了LC/MS/MS，而無須繁複的樣品前處理，也無須進行衍生化反應，即可分析安非他命、鴉片類藥物、苯二氮平類、GHB及許多其他藥物。LC/MS/MS的靈敏度允許僅使用少量樣品。因此除血液、血漿或尿液外，也可使用來自替代基質的容積限制樣品，例如毛髮、汗水或唾液。MassTrak™ 系統配備有TargetLynx™ application manager，可在單次分析中以高度信心定量及驗證濫用藥物。

LC/MS/MS對於不易由氣相層析(GC)分析的極性、非揮發及熱不穩定化合物尤其有用。對於高通量實驗室或需提供快速結果的實驗室而言，LC/MS/MS為理想的技術。一旦具備了LC/MS/MS，大多數藥物均不需繁複的樣品前處理或進行衍生化反應即可進行分析。除血液、血漿或尿液外，LC/MS/MS的靈敏度允許使用來自替代基質的容積限制樣品，例如毛髮、汗水或唾液。

Underpinning our customers successes are Waters Services and Support initiatives which are designed specifically for clinical laboratories looking for performance optimization and the reassurance that they can get on-site support if an issue should arise. Waters provides priority on-site services, repairs, telephone support, and offers optional remote monitoring and diagnostic capabilities minimizing any downtime and optimizing your investment. Waters is committed to the results you gain from our integrated system solutions.

As such, the program sets new standards for MassTrak™ Systems support in your clinical laboratory.

• Guaranteed prioritized service
• Guaranteed two-hour response for callback after receipt of a support call
• Guaranteed on-site response time of two business days (48 hours)
• Single vendor support for HPLC and mass spectrometry systems and applications

LC-MS/MS is particularly useful for polar, non-volatile and thermally labile compounds that are difficult to analyze by gas chromatography. It is also the ideal technique for high-throughput laboratories or those tasked with providing rapid results.

In addition to the common illicit drugs such as amphetamines, opiates, cannabis and cocaine, many prescribed ‘legal' drugs have a high potential for abuse and are knowingly abused or accidentally misused e.g. benzodiazepines and the prescribed opiates, methadone and buprenorphine.

Waters' Toxicology application group has extensive expertise in developing and refining

LC-MS/MS methods for the quantification of a wide range of drugs of abuse in a diverse variety of sample matrices.

Some of these methods include:

• Amphetamines from plasma, urine and saliva
• Basic drugs in oral fluid
• THC in preserved oral fluid
• Opiates from plasma and urine
• Benzodiazepines from plasma and urine
• Psychotherapeutics in human serum
• Antipsychotics in plasma

The ACQUITY TQD is the perfect system for laboratories requiring easy to use, high-quality analytical information without the burden of complicated operation and time-intensive troubleshooting and maintenance.

The Waters^® TQ Detector offers a new generation of mass spectrometry detection, specifically designed for high throughput laboratory environments. Forensic laboratories will benefit from robust and reliable performance and walk-up operation for users with any level of expertise.

ACQUITY TQD system benefits include:

• Performance and Ease of Use
• Innovative fast scanning MS/MS detection, combined with UPLC technology
• High sensitivity, combined with ease of use
• Simplified operation compared to conventional LC-MS/MS systems
• Intuitive and user-friendly diagnostic software
• Integrated support software with on-line proactive service support
• Smallest footprint of any tandem quadrupole instrument available