Waters offers a comprehensive range of analytical system solutions, software, and services for scientists. Liquid Chromatography. Mass Spectrometry. Waters is the leading provider of lab equipment, supplies and software for scientists across the world. Easily research and order everything your lab needs! Waters offers a comprehensive range of analytical system solutions, software, and services for scientists. Liquid Chromatography. Mass Spectrometry. Waters is the leading provider of lab equipment, supplies and software for scientists across the world. Easily research and order everything your lab needs!

Glycan Application Solution

Confident assignment of glycan structures based on retention (in Glucose Units) with accurate mass confirmation

The Waters Biopharmaceutical Platform Solution and Glycan Application Solution provide workflows and toolsets to assist scientists in characterizing and monitoring the key quality product attributes of complex biotherapeutic proteins.

Facilitate data standardization and exchange among departments and third party partners, globally
Enable all laboratory functions to work with a common backbone of analytical information, comprising successful methods, processed results, historical data, and reports
Break down barriers between acquiring analytical knowledge and making information-driven decisions

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Waters offers all of the analytical tools to ensure successful released N-glycan analysis.

GlycoWorks Sample Preparation and Standards for 2-AB and RapiFluor-MS
Waters Glycan Separation Technology Columns for UPLC, UHPLC and HPLC
ACQUITY UPLC H-Class or H-Class Bio System, featuring a bio-inert flow path and quaternary solvent management with Auto•Blend Plus Technology
Xevo G2-XS QTof Mass Spectrometer, for the most sensitive exact-mass quantitative and qualitative MS, in a benchtop system designed with Engineered Simplicity
UNIFI Scientific Information System, an interactive workflow-driven data platform for flexible instrument control, advanced data processing and mining, and comprehensive reporting, with GxP laboratory compatibility that enables routine deployment throughout your organization

Proven Databases

Experimentally-derived glycan GU retention time databases covering the diversity of glycan structures found in biotherapeutic proteins and industry-leading released N-glycan analysis labels (2-AB and RapiFluor-MS)

GlycoBase 3+ database, a first-of-its-kind library developed in collaboration with NIBRT of dextran calibrated chromatographic retention values, expressed in glucose units, for a diverse array of glycan structures associated with biotherapeutics and other glycoproteins of biological interest
GlycoBase derived Glycan GU databases supporting UPLC HILIC and HILIC-MS analysis of 2-AB and RapiFluor-MS labeled glycans are available from Waters as integrated scientific libraries within UNIFI. Combined with the UNIFI glycan analysis workflows, these libraries automate the analysis of glycoproteins, including the determination of glycan GU calibrated retention times and assignment of glycan structures within those profiles.

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Workflow 1- Glycan FLR with MS confirmation

Versatile Workflows

Two independent analytical glycan workflows that allow scientists to characterize and monitor glycan profiles using both optical (fluorescent) and/or MS (MS) data generated within an integrated UPLC/FLR/QTof MS system. These workflows enable researchers to assign and quantify low abundance glycan structures with higher confidence.

1) Released Glycan FLR (with optional MS confirmation) for the generation of quantitative glycan profiles with high confidence through accurate mass conformation.

2) Released Glycan DDA workflow enabling fluorescence-based quantification of profiles and independent MS/MS confirmation via data export to SimGlycan (Premier Biosoft) for structural assignments.

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Biopharmaceutical Platform Solution with UNIFI - Application Notebook

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