Acquire data points faster without without loss in sensitivity

Xccelerated Ion Transfer (XIT^TM) electronics, using SpaceWire technology allow this instrument to acquire data at extremely high speeds without compromising performance. The next generation T-Wave^TM collision cell permits acquisition of 500 MRM channels/s whilst minimizing cross-talk and maintaining intensity. The increased MS full scan speed capability of up to 20,000 Da/s reduces the impact on the duty cycle when rapidly switching between MS full scan and MS/MS acquisition (RADAR and PICs).

 In addition, fast polarity switching gives coverage of positive and negative ionizing compounds in a single injection. Maintaining performance at these speeds is critical as every clinical laboratory requires high quality data that is reproducible to enable reliable quantification. Method transfer is now even easier with the advanced XDR detector which provides unique Xtended Dynamic Range improving usability with low limits of detection.

Understanding sample complexity in clinical LC-MS/MS method development

Challenges for quantitative methods include:

• Performing targeted analysis for analytes of interest and detecting unexpected analytes in the same injection
• Characterization of background matrix for every sample throughout each run to improve data quality
• Examining matrix background during method development to better characterize targeted methods for interferences as well as ion enhancing and ion suppressing species

These challenges may be overcome by using RADAR which is the ability to obtain full scan (MS) and MRM (MS/MS) data simultaneously.