Reproducible, ultimate sensitivity quantitation

Whether you are analyzing small or large molecules, single analytes or multiple panels of compounds, the Xevo TQ-XS will give you the results you need, first time and without complication.

The new StepWave XS ion guide provides improved sensitivity that is reproducible for multiple injections and can provide reliable quantitation at the very lowest levels. StepWave XS ensures neutrals and gas load are passively removed for enhanced transmission, with the ions actively transferred into the mass analyser, improving sensitivity and robustness. The first stage is modified with a series of horizontal plates that allows a more controlled extraction of ions from the gas flow so that ions collide with gas molecules with less energy.

A segmented quadrupole second stage focuses the ion beam to provide more efficient transmission of ions from the source to the detector.

Pushing the boundaries – leading technology

The key technologies that enable you to do more with your instrument start with UniSpray™ which ionizes a wider range of compounds than any other single technique. Combining wider compound coverage with an extremely easy to use source, UniSpray can deliver results to your laboratory for more compounds than before, without having to change source or probe. So you can spend more time delivering results and less time changing instrument parts.

Robust results you can trust with the most demanding sample matrices

The routine challenges of complex matrices are overcome by the Xevo TQ-XS which provides reproducible results injection after injection despite difficult sample matrices. In a study involving 2,000 injections of protein-precipitated plasma and analyzing sulphadimethoxine, there was little variation in peak area over the entire injection series with <3% RSD. This study aimed to reproduce the challenging conditions found in many analytical laboratories by also using a short dwell time of only 5 ms.

Tool –free probe optimization and maintenance

Redefine the way that you operate your instrument with the new atmospheric pressure ionization probes available on the Xevo TQ-XS. You don’t need to worry about time-consuming optimization steps with any tools. Even changing the probe assembly including the capillary is entirely tool-free. Ensure that you get the same results no matter who operates and maintains the instrument probes, for improved reproducibility over much longer periods of time.

Making sensitivity accessible with the Xtended Dynamic Range detector

When you need to measure analytes at very different concentrations within the same sample, it is very time-consuming to dilute samples and re-inject in a separate experiment to bring values within calibration curves. With the Xtended Dynamic Range (XDR™) detector there are now six orders of linear dynamic range, enabling you to quantitate a wider range of analyte concentrations without saturating the detector in a single injection.

Improved lab efficiency – better usability

Waters’ laboratory informatics software provides a powerful suite of solutions allowing you to convert scientific data into useful information. In an environment where time is of the essence, you need a solution that will maximize your efficiency. Focus on what you do with the data, not how you get it, so you can accelerate decision making, improve laboratory effectiveness, and get results faster.

High Productivity, Minimal Complexity
Intellistart™ simplifies system setup with a user-friendly interface.

Simple, Integrated Method Databases
The searchable QUANPEDIA™ database allows for optimal LC-MS/MS quantitative method building.

Critical QC Information Delivered Real Time
Automated real-time QC checking ensures that valuable samples and instrument time are not wasted.

Comprehensive Data Processing with Streamlined Results Review
TargetLynx XS™, including standard addition, streamlines automated quantitative data review and reporting, minimizing the possibility of errors. This software provides a clear overview of QC checks, statistics and results, flagging any results outside user-defined tolerances.

Confidence in Your System Performance
Trending inter and intra-batch QC and sample results over time is easy with TrendPlot, which has clear graphical displays to enable quick decision making.