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Simultaneous in vivo Quantification and Metabolite Identification of Plasma Samples Using High Resolution QTof and Routine MSE Data Analysis
This application note summarizes the collaboration between Vertex and Waters to test and demonstrate a quan/qual workflow to determine robustness and reliability of QTof measurements, and compare them against the gold-standard tandem quadrupole workflows.
In this example, propranolol was used as a model compound and a pharmacokinetic (PK) rat study (containing standard curves, PK runs, and QCs) was conducted by Vertex Pharmaceuticals using a Xevo G2 QTof MS System for analysis. The sample set was also run at Vertex using a triple quadrupole platform with a typical MRM-based workflow under the same chromatographic conditions to provide a reference comparison data set.
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