Development of analytical methods for the detection of contaminants in food is often challenging due to the complexity of the matrix. In LC/MS/MS, co-eluting matrix components may compete with the analyte of interest during the ionization process, which can lead to suppression or enhancement of the analyte signal. It is therefore necessary to characterize these potential matrix effects during method development and eliminate or minimize their impact on the quantification of the analyte. Minimizing the matrix components also helps to ensure method robustness. The ability to monitor matrix interferences by simultaneously monitoring full scan background data during quantitative MS/MS method development represents an important advance in instrument design. The Xevo TQD employing RADAR functionality provides an innovative platform to observe MRM (multiple reaction monitoring) data and full scan background data simultaneously for faster, more robust method development.