The Utility of MSe for Toxicological Screening
Laboratories are frequently required to perform broad screening techniques on complex biological samples to identify drugs of abuse and other toxicants. In recent years there has been an increased interest in the use of Time-of-Flight (Tof) instruments for this purpose due to the high level of specificity offered by exact mass data. While exact mass libraries can be automatically generated without reference material i.e., from molecular formulae, the lack of additional information can lead to false positive results in the analysis of authentic samples. Thus, where possible, additional information e.g., an associated retention time (RT) and confirmatory fragment ions should be used to increase confidence in drug identification and to improve the ease and speed of data review and reporting. Here we demonstrate the use of UPLC/MSe for the screening of toxicants in human urine.
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