Waters offers a comprehensive range of analytical system solutions, software, and services for scientists. Liquid Chromatography. Mass Spectrometry. Waters is the leading provider of lab equipment, supplies and software for scientists across the world. Easily research and order everything your lab needs! Waters offers a comprehensive range of analytical system solutions, software, and services for scientists. Liquid Chromatography. Mass Spectrometry. Waters is the leading provider of lab equipment, supplies and software for scientists across the world. Easily research and order everything your lab needs!
Characterization of Protein Impurities by Peptide Mapping with UPLC/MSE
In this application note, we demonstrate an application of MSE, using the Waters SYNAPTTM MS System coupled with UltraPerformance LC® (UPLC®), for characterization of a yeast enolase tryptic digest. Multiple protein contaminants as well as unexpected peptides resulting from non-specific digestion were identified. The results demonstrate that UPLC/MSE methodology is capable of identifying and quantifying low-level impurities in protein products. LC peaks from unexpected partially tryptic and non-tryptic cleavages are assigned and distinguished from peptides originating from impurity proteins.
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