High Sequence Coverage Peptide Mapping of a Monoclonal Antibody with UPLC/MSE

Library Number:
APNT10099389
Part Number:
720002821en
Author(s):
Hongwei Xie, Martin Gilar, John C. Gebler
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Application Notes
Related Products:
 
 
 
 
SYNAPT MS

UPLC/MSE is capable of characterizing digests of large, complex proteins such as monoclonal antibodies, with very high sequence coverage for both the heavy and light chains. Additionally, covalent modifications such as N-deamidation and N-linked glycosylation, can be identified. Peptide identifications are also supported by the high-quality MSE data.


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