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Analysis of Deamidation and Oxidation in Monoclonal Antibody using Peptide Mapping with UPLC/MSE
This application note demonstrates that UPLC/MSE is a suitable tool for characterizing PTMs in monoclonal antibodies. Using UPLC/MSE with the ACQUITY UPLC and SYNAPT MS systems, the identification of peptide sequences and determination of site-specific moditications can be accomplished in a single LC run because of available peptide fragmentation information provided by MSE.
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