Understanding sample complexity
Some challenges for quantitative methods are:
- Calculating compound concentrations in addition to the detection of unexpected contaminants.
- Characterization of the background matrix for every sample, increasing data quality.
- Detection of analytes that are not in a targeted multiple reaction monitoring (MRM) screening method.
- Improving method development by discovering more matrix components.
These challenges may be overcome by using RADAR which is the ability to obtain full scan (MS) and MRM (MS/MS) data simultaneously.
Product Ion Confirmation scanning (PICS) allows you to have full confidence in your results. Activated by a single check box in the method editor, PICS automatically triggers a product ion scan when a peak is detected by MRM.