Waters offers a comprehensive range of analytical system solutions, software, and services for scientists. Liquid Chromatography. Mass Spectrometry. Waters is the leading provider of lab equipment, supplies and software for scientists across the world. Easily research and order everything your lab needs! Waters offers a comprehensive range of analytical system solutions, software, and services for scientists. Liquid Chromatography. Mass Spectrometry. Waters is the leading provider of lab equipment, supplies and software for scientists across the world. Easily research and order everything your lab needs!

UniSpray Ion Source

A novel ion source for ionization of a broader range of compounds

The UniSpray™ ion source allows you to see more of your sample within a single analysis when compared to ESI, APCI or APPI. This enables UniSpray to offer:

Greater ionization efficiency - A broader range of compounds ionized in a single run and potential for increased sensitivity
Reduce the need to change ionization source between different analyses
Tool free routine maintenance - capillary and target pin replacement

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The UniSpray ion source - See more of your sample in a single analysis.

Overview

Literature

Application Notes

Support

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UPLC/MRM data on the Xevo TQ-XS with UniSpray ion source showing improved sensitivity for three compounds that would typically require a change in ionization technique for optimal analysis.

Expanding the breadth of ionization

The unique geometry of the UniSpray ion source generates several different mechanisms to produce smaller droplets and enhance desolvation. These effects combine together to generate a greater number of free ions from the same amount of sample when compared to traditional ionization modes such as electrospray and typically results in an increase in response across a wide range of compounds.

The combination of a broader range of analytes and a potential boost in response give the possibility to consolidate several analysis methods into one, or even just remove the need to change over sources between analyses, saving you time and increasing your laboratory efficiency.

Robust, reproducible and easy to use

The single piece probe design and bespoke probe adjuster on the UniSpray ion source allow for simple optimization and tool free routine maintenance of the UniSpray source, ensuring you get the same results, no matter who operates and maintains your instrumentation. In a study of 1000 injections of protein precipitated plasma, analyzing for caffeine, <3% RSD was observed across the entire series of injections.

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UPLC/MRM data on the Xevo TQ-XS with UniSpray ion source showing excellent reproducibility for 1000 injections of caffeine in protein precipitated human plasma.

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Waters Xevo TQ-XS with the UniSpray ion source

High efficiency, broad applicability

Available on the full range of Waters Universal Ion Source compatible mass spectrometers, UniSpray expands the scope of your analysis by enabling a wider range of analytes to be ionized in a single run and delivering results for more compounds than ever before without having the change sources.