Clinical research laboratories can improve analytical selectivity, accuracy, and sensitivity by using mass spectrometry for monitoring and quantifying levels of therapeutic drugs in biological matrices.
Traditional methods used for the measurement of therapeutic drugs in biological matrices have presented numerous challenges for clinical research laboratories. For example, immunoassays can be non-specific and may cross-react with drug metabolites, leading to over-estimation of the parent drug.
Offering increased selectivity that minimizes interfering compounds, UPLC-MS/MS provides greater accuracy and sensitivity for a variety of therapeutic drug applications in clinical research laboratories.