Understanding sample complexity

RADAR is an acquisition mode that acquires both MRM and full scan MS simultaneously, a unique capability that can both simplify and accelerate development of robust methods.

• Track interferences during method development, to optimise chromatography
• Capture positive and negative ion data to monitor matrix interferences during a routine quantitative analysis
• Obtain a full picture of the sample, not just the target analyte, by enabling detection of impurities, degradants or metabolites
• RADAR is a standard feature of all Xevo® tandem quadrupole MS systems.

Intelligent method development

The ability to review qualitative and quantitative data acquired simultaneously enables better method development decisions to be made, based upon the acquired data for the target compounds and visualization of the matrix background.

Visualization of both target compounds and matrix enables informed choices to be made on sample preparation methods and mobile phase composition/gradient to ensure optimum separation from co-extracted compounds, offering the potential for methods with minimized matrix effects.

Understanding matrix effects

During routine analysis, RADAR offers the ability to understand unexpected results due to matrix effects. Most samples injected may satisfy QC criteria, however in some cases matrix effects may be present for a specific compound/matrix combination.

RADAR enables these effects to be understood, helping to explain ion suppression when a co-eluting matrix component at a high concentration can be observed in the RADAR full scan trace.