Improved LC-MS analysis of peptides and proteins

It can be difficult to predict peptide losses due to non-specific binding and ionic interactions, as it can be dependent on many characteristics, such as pI and hydrophobicity. Demonstrated here are the recovery of four different peptides. The recovery of desmopressin is not affected by the sample container, while glucagon, insulin, and melittin suffer varying losses due to non-specific binding and ionic interactions in the glass and standard polypropylene containers. 

Only QuanRecovery Vials and Plates with MaxPeak HPS protect these peptides from loss, in turn, producing high recovery and repeatability.

Use it! Don't lose it! 

Improved recovery and sensitivity at high and low sample concentrations

Biomolecule sample losses are a problem at low concentrations. However, non-specific binding and ionic interactions can also cause losses at higher concentrations.

When comparing the sensitivity of glucagon at 1 ng/mL stored in a QuanRecovery Plate versus standard polypropylene, better sensitivity (11x) is observed with the QuanRecovery Plate. Additionally, we performed the same container comparison with insulin at a much higher concentration (100 ng/mL), and even at this higher concentration, we observe that the sensitivity is higher (2x) in the QuanRecovery Plate versus standard polypropylene.

This means that sensitivity, recovery, and repeatability can be affected at higher concentrations as well as lower concentrations. 

QuanRecovery Vials and Plates with MaxPeak HPS protect your sample, ensuring improved analytical results.

MaxPeak High Performance Surfaces

MaxPeak High Performance Surfaces are new and innovative technologies designed to increase analyte recovery, sensitivity, and reproducibility by minimizing analyte/surface interactions that can lead to sample losses.