Based upon first generation hybrid (inorganic/organic) particles, the XTerra® family of HPLC columns enables chromatographers to perform high pH drug discovery, method development and purification separations.

XTerra® Columns combine the best properties of silica and polymeric bonded phases with patented Hybrid Particle Technology that replaces one out of every three silanols with a methyl group during particle synthesis. This hydrophobicity is distributed through the entire structure of the particle backbone, resulting in a rugged hybrid particle that can be operated at high speeds, high temperatures and at high pH. The presence of 33% fewer residual silanols (after endcapping and bonding) also means that XTerra columns give exceptionally sharp, high-efficiency peaks for basic compounds.

Extend column lifetime with VanGuard Column Protection Products