Atmospheric Pressure Chemical Ionization (APCI) is an effective method for analyzing lower-polarity compounds. The high-efficiency IonSABRE™APCI probe offers significant improvements in sensitivity compared with earlier versions of probe, particularly at higher liquid flow rates.

Ionization Process

With APCI, the sample stream is nebulised and analytes are desolvated using a combination of gas flow and high temperatures. The desolvated compounds are ionized by charge transfer as they pass through a plasma created by a corona discharge. Flow rates up to 2 ml/min are acceptable.

The IonSABRE APCI probe with thermally enhanced heater design provides improved heat distribution and sample vaporization. The support gas flow also maximizes transmission of sample droplets into the ion source.

Together, these features provide optimum APCI performance leading to superior limits of quantitation in compound quantification and identification studies.

Instrument Compatibility

The IonSABRE APCI probe is available for the following MS instruments:

• ACQUITY™ SQD/TQD, 3100, SQ Detector 2, Xevo™ TQD
• Xevo TQ MS, Xevo TQ-S, Xevo TQ-S micro
• Xevo G2 QTof, Xevo G2-S QTof, Xevo G2-XS QTof
• Xevo G2 Tof,  Xevo G2-S Tof, Xevo G2-XS Tof
• Xevo TQ-XS
• MALDI SYNAPT MS, MALDI SYNAPT HDMS
• SYNAPT G2 MS, SYNAPT G2 HDMS, MALDI SYNAPT G2 MS, MALDI SYNAPT G2 HDMS
• (MALDI) SYNAPT G2-S  MS, (MALDI) SYNAPT G2-S HDMS
• (MALDI) SYNAPT G2-Si MS, (MALDI) SYNAPT G2-Si HDMS

*An additional conversion kit is included with the LCT Premier IonSABRE probe option to allow Ion Sabre APCI Exact Mass experiments.

Equipment and Installation

The accessory kit comprises:

• IonSABRE probe and Corona pin
• Spare parts kit and User operation guide
• Free-standing power supply unit ( selected instrument only)

Although the accessory is easy to install, Waters strongly recommend installation and operation confirmation/training by a Field Service Engineer.