Waters offers a comprehensive range of analytical system solutions, software, and services for scientists. Liquid Chromatography. Mass Spectrometry. Waters is the leading provider of lab equipment, supplies and software for scientists across the world. Easily research and order everything your lab needs! Waters offers a comprehensive range of analytical system solutions, software, and services for scientists. Liquid Chromatography. Mass Spectrometry. Waters is the leading provider of lab equipment, supplies and software for scientists across the world. Easily research and order everything your lab needs!

Biomarker Translation

It’s time to smooth the bumps in the road with Waters solutions for biomarker translation

Waters' solutions for biomarker verification and validation facilitate a smooth translation from discovery experiments to robust, high throughput, and high-sensitivity quantitative methods using tandem quadrupole or high-resolution time-of-flight MS systems. LC-MS based methods overcome many of the limitations of antibody-based techniques, such as ELISA or protein arrays, such as poor reproducibility, antibody development time, batch-to-batch reagent variability and the lack of multi-plexing capabilities. For protein biomarker validation in large sample cohort studies, scientists had to choose between nano-flow LC for high sensitivity or normal flow LC for throughput and robustness.

With the ionKey/MS system, scientists no longer have to make this choice and can now quantify low abundant protein biomarkers with high throughput and high sensitivity.

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Overview

Literature

Application Notes

For protein biomarker studies, Waters LC-MS technologies deliver the fastest transition from discovery to targeted assays by expertly selecting proteotypic peptides for quantitative protein assays along with optimum Multiple Reaction Monitoring (MRM) parameters. By automatic integration with Skyline Informatics, targeted UPLC-MS/MS methods can be rapidly developed and implemented.

Waters' ionKey/MS System, a micro-fluidic separations device interfaced with Waters tandem quadrupole or high resolution time of flight platforms, offers unmatched performance for biomarker verification studies. With ionKey/MS, new levels of sensitivity, reproducibility and robustness is achieved at flow-rates of 1 nL/min. IonKey combines the sensitivity of microflow with a new level robustness and ease-of-use.

Key Technologies

	ionKey/MS ionKey/MS is the integration of the UPLC® separation into the source of the mass spectrometer delivering a level of sensitivity, chromatographic performance, robustness and ease-of-use that is unachievable by any other MS system.
	ACQUITY UPLC M-Class System The most reliable and highest performing nano- to microscale instrument available to deliver UPLC-quality (UHPLC) separations ― providing more sensitivity to every laboratory performing LC-MS analyses.
	Xevo TQ-S micro A robust and sensitive tandem quadrupole MS with compact design, featuring unparalleled performance with a wide dynamic range and high rates of data acquisition.
	Xevo TQ-XS Triple Quadrupole Mass Spectrometry Waters’ most sensitive mass spectrometer, the Xevo TQ-XS Tandem, commonly known as Triple Quadrupole Mass Spectrometer expands the scope of ultimate sensitivity analysis, leading to unprecedented levels of reliability, reproducibility and performance.
	Xevo G2-XS QTof A benchtop QTof mass spectrometer incorporating the XS Collision Cell for enhanced sensitivity and selectivity, resulting in the highest quality, most comprehensive qualitative information together with the ultimate in quantitative performance.
	ProteinWorks Routinely achieve reproducible, accurate, and sensitive protein quantification with ProteinWorks, Waters family of protein bioanalysis sample preparation kits.