For the isocratic UPLC analysis of analytes without a UV chromophore, the ACQUITY UPLC Refractive Index (RI) Detector offers unparalleled performance.  Its low-dispersion fluidics are designed to match the performance needed for narrow UPLC peaks while still delivering stable baseline performance, low noise, and a wide, linear dynamic range.  

Refractive index detection is one of the key enabling technologies in the ACQUITY Advanced Polymer Chromatography (APC) System.  The low-dispersion characteristics of the ACQUITY UPLC RI Detector are critical for maintaining the high-resolution molecular weight separations achieved on the ACQUITY APC columns, delivering unprecedented characterization of low molecular weight polymers and their oligomers.

HPLC/RI applications, including sugars, alcohols, saccharides, and pharmaceutical QC, can easily be transferred to UPLC system technologies to enable improved resolution and reduced analysis times.

The transfer of HPLC USP method for topiramate to the ACQUITY UPLC H-Class System with the ACQUITY RI Detector has resulted in 80% reduction in runtime while maintaining equivalent chromatographic performance.

• Detection of samples without UV chromophores separated by isocratic analysis
• Low dispersion design, for compatibility with narrow UPLC and APC peaks
• Full compatibility with a wide range of solvents supported on the ACQUITY APC System
• Sampling rates up to 80 points/s with independent optimization of filter time constants, for the highest resolution and sensitivity
• Highly repeatable detection technique with a wide linear dynamic range for methods requiring quantification
• Thermally isolated optics bench for temperature stability and performance reproducibility
• Countercurrent heat exchanger to quickly equilibrate temperature differences of incoming solvent
• Save solvent and maintain stability with the convenient recycle valve
• Full control in the instrument console, giving access to instrument status and diagnostics