ACQUITY UPLC I-Class / Xevo TQ-XS IVD System

With patented StepWave technology, our highest performance IVD instrument provides ultimate sensitivity, to accurately quantify trace analytes in the most complex of clinical matrices encountered

Designed for the most demanding quantitative LC-MS/MS applications, the ultimate in tandem quadrupole performance allows you to achieve the highest sensitivity and robustness available to clinical laboratories.
Class leading sensitivity and robustness with qualitative information when you need it most, the ACQUITY UPLC I-Class / Xevo TQ-XS IVD offers:

StepWave XS ion guide that provides increased sensitivity for challenging compounds
Enhanced detection system with six orders of linear dynamic range to ensure high performance across your analytical concentration range
Tool-free probe design reduces the time taken for any routine maintenance and provides improved reproducibility between users
Accelerated method development for sensitive and robust methods
Improved workflow and data transfer through connectivity with liquid handling robots and the HL-7 compliant MassLynx LIMS Interface

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ACQUITY UPLC I-Class / Xevo TQ-XS IVD System

Overview

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Application Notes

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Complex challenges, solved

With industry-leading separations performance, the ACQUITY UPLC I-Class System provides the most powerful solution to the most critical need in separation science today – successfully analyzing clinical compounds that are limited in amount or availability amid a complex matrix, more rapidly than ever before. Developed to produce the most accurate and reproducible separations, you will get the most information possible and accelerate laboratory results.

Robust results you can trust with the most demanding sample matrices

The Xevo TQ-XS IVD is a highly advanced tandem quadrupole mass spectrometer designed for your most demanding quantitative UPLC/MS/MS applications. The new StepWave XS ion guide provides improved sensitivity that is reproducible for multiple injections and can provide reliable quantitation at the very lowest levels, allowing the measurement of trace analytes in complex matrices in the clinical laboratory.

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2,000 injections of sulphadimethoxine in protein precipitated plasma with 2.55% RSD.

Comprehensive and streamlined results review with TargetLynx XS software which flags any results outside user-defined tolerances.

Making sensitivity accessible with the Xtended Dynamic Range detector

When you need to measure analytes at very different concentrations within the same sample, it is very time-consuming to dilute samples and re-inject in a separate experiment to bring values within calibration curves. With the Xtended Dynamic Range (XDR™) detector there are now six orders of linear dynamic range, enabling you to quantitate a wider range of analyte concentrations without saturating the detector in a single injection.

Tool – free probe optimization and maintenance

Redefine the way that you operate your instrument with the new atmospheric pressure ionization probes available on the Xevo TQ-XS. You don’t need to worry about time-consuming optimization steps with any tools. Even changing the probe assembly including the capillary is entirely tool-free. Ensure that you get the same results no matter who operates and maintains the instrument probes, for improved reproducibility over much longer periods of time.

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Routine Maintenance of the ESI and APCI probes has never been so easy

TargetLynx XS Improving Data Processing

MassLynx Software with TargetLynx XS increases the speed at which you can convert your sample data into valuable knowledge. It provides you with the fundamental platform to acquire, analyze and manage data information in a clinical environment.

Automated Data Workflow Solutions

The MassLynx LIMS interface, conforming to the Health Level 7 protocols (HL7), automates the exchange of information with a third-party LIMS provider, improving the data workflow while minimizing transcription errors. The MassLynx Tecan File converter and direct connection with Hamilton automatic liquid handlers provides sample tracking from primary tube to result without operator intervention, providing secure data transfer and reducing transcription errors.