ACQUITY Arc Bio System

The solution for your daily bioseparations challenges

Engineered with bio-inert flow paths made of iron-free materials, the ACQUITY Arc Bio System keeps large molecules intact and on the move, for better sample recovery and minimal carryover, whether the chromatographic mode is reversed phase (RP), ion exchange (IEX), size exclusion (SEC), or hydrophobic interaction (HIC).

Built upon the reliable foundation of the ACQUITY Arc System, the ACQUITY Arc Bio System is designed with novel Arc Multi-flow path technology to provide the versatility and robustness required to efficiently transfer, adjust, or improve your methods without compromising method integrity.

Regulatory compliant-ready hardware and software for both HPLC and UHPLC separations in one instrument
Experience true plug-and-play HPLC and UHPLC bioseparations
Modernize existing legacy methods
Accelerate analytical assays designed to assess biotherapeutic quality attributes related to safety, stability and efficacy
New array of columns containing 2.5 µm particles developed and QC tested to deliver optimal performance on HPLC or UHPLC platform

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Reliable operation under demanding conditions

Assays utilizing SEC, IEX and HIC modes of chromatography typically utilize high ionic strength mobile phases, often under basic or acidic conditions. The ACQUITY Arc Bio System’s flow paths are made of bio-inert materials to minimize undesirable protein interactions and maximize system robustness under salt and pH extremes. The result: a system that is ideally suited for routine, trouble-free operation with negligible carryover and maximum recovery of biomolecules for consistently high system performance.

Replicate your existing methods

Analytical laboratories can’t afford to use anything but the most reliable and robust equipment to ensure product consistency and compliance with regulatory guidelines. Analytical laboratories must also commonly transfer methods across the organization, or to contract partners, while preserving method integrity.

Upgrade your analytical laboratory with the ACQUITY Arc Bio System, a versatile, biocompatible LC system that delivers HPLC and UHPLC method compatibility at the flip of a switch.

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Cation-exchange separation of infliximab

Streamline your method development

The bioQuaternary Solvent Manager automatically blends mobile phase combinations and gradients on demand, enabling you to achieve retention and critical resolution requirements for your analysis. Designed with bio-inert materials, the bioQuaternary Solvent Manager accommodates the range of aqueous, high ionic strength mobile phases and organic solvents used in several biopharmaceutical LC applications.

Auto•Blend Plus Technology extends traditional quaternary solvent blending to permit gradient programming directly in units of pH and ionic strength, providing the ability to vary composition in even the smallest increments of pH (even those differing by 0.1 pH units or less).

Develop methods that stand the test of time

The ACQUITY Arc Bio System is fully compatible with the ACQUITY QDa Mass Detector, supporting efficient and robust method development by expanding the information you can get from your system using the same Empower Software. The system automatically pairs qualitative mass spectral data to the peaks in your chromatogram leaving nothing to chance.

Confirm the identity of peaks in a separation without injecting standards
Identify new peaks in a separation with molecular weight information
Detect unresolved peaks and determine if a peak is homogenously pure
Easily track peaks as method conditions are changed

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Method transfer of USP Assay for Fluconazole using the ACQUITY Arc System. Here the peak has same m/z of a related compound. 1. Related compound A; 2. Related compound B; 3. Related compound C; 4. Fluconazole.

Features and Benefits

Quaternary solvent blending. Blend up to four solvents in any combination or proportion. Expand to up to nine solvent choices with the optional and integrated solvent-select valve for even greater flexibility.
Plug-and-play method compatibility with HPLC or UHPLC with the flip of a switch. Easily replicate or improve established methods by simply selecting Path 1 (HPLC) or Path 2 (UHPLC) without any manual user intervention. Automatically counteract differences in system dwell volume without the need to alter gradient table inputs.
Minimize carryover (≤0.002%) by continuously cleansing the needle during the run with an advanced flow-through-needle design.
Flexible column manager options available for up to 15 columns ranging in length from 50 mm to 300 mm, with a temperature range of 4 °C to 90 °C. Provide stable, uniform temperature management with integrated active or passive pre-heating options to ensure method repeatability from lab to lab. Optional and integrated column selection valve provide fast, unattended column changeover.
Directly program gradients in units of pH and ionic strength with Auto●Blend Plus Technology, providing the ability to vary composition in even the smallest increments of pH. This eliminates the cumbersome and error-prone approach of manually preparing mobile phase solutions.
Maximize HPLC and UHPLC performance with a full line of optical detection options.
Push-button mass detection with the ACQUITY QDa Mass Detector.
Compliance-ready. Qualification of laboratory instrumentation is an integral part of compliance with regulatory and quality standards such as GMP, GLP, ISO 17025, USP <1058>, and others. The ACQUITY Arc Bio System supports Waters Empower based automated system qualification tool (SQT), which minimizes the time and cost associated with annual qualification.
Consumables. Industry leading selectivity choices to meet the needs of virtually every LC application. Quality Control Reference Material benchmarks your ACQUITY Arc Bio System and enables perfect resolution. Certified clean vials.
Supported in both Empower and MassLynx Software.

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ACQUITY Arc Bio System

The solution for your daily bioseparations challenges

Reliable operation under demanding conditions

Replicate your existing methods

Streamline your method development

Develop methods that stand the test of time

Features and Benefits

Contact Waters

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