2424 Evaporative Light Scattering (ELS) Detector
Putting confidence in your detection strategy
Detecting semi- and non-volatile compounds with minimal UV absorbance is a challenge. The Waters 2424 Evaporative Light Scattering (ELS) Detector, with its compact and innovative design, offers near universal detection of non-volatile and semi-volatile sample components.
The 2424 ELS Detector is compatible with both isocratic and gradient separations and has nebulizer options to cover a wide range of analytical and microbore flow rates. By adding the orthogonality of ELS to your detection strategy, you increase peak detection confidence across a wide application space. The 2424 ELS Detector can be used as part of an LC or LC-MS system under the control of Empower or MassLynx software or can be operated as a standalone detector.
Specifications
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Nebulizers |
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High-flow rate (standard with detector) |
300 to 3000 μL/min, (gas flow at 1.80 L/min at 25 psi) |
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Optional low-flow rate |
50 to 500 μL/min, (gas flow at 0.77 L/min at 25 psi) |
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Temperature control |
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Nebulizer heater power |
0% to 100% |
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Nebulizer cooler |
On/off |
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Drift tube |
Ambient +5.0 to 100.0 °C; 0.1 °C increments |
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Optional external column heater |
Ambient +5.0 to 150.0 °C; 1.0 °C increments |
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Gas supply |
Nitrogen, to be supplied at least 65 psi |
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Gain setting |
0 to 1000 |
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Filter time constant |
Hamming, 0.0 to 5.0 s |
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Sampling rate |
Up to 80 points/s |
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Measurement range |
0.1 to 2000.0 LSU |
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Optics |
Heated optics bench (constant 50 °C) |
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Light source |
Tungsten halogen polychromatic front mounted, pre-aligned, user installable Warranty: 2000 hours or 1 year warranty (whichever comes first) |
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Detector |
Photomultiplier tube |
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Scattering angle |
60 degrees |
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Wetted materials |
316 stainless-steel, aluminum, viton, PTFE, FEP, silicone rubber, polyethylene, polyurethane |
Overview
- Active nebulizer heating and cooling for method optimization and rapid stabilization
- 60° scatter angle detection to minimize stray light and optics polarization for long-term optimal sensitivity
- Optimal energy output for improved bench-to-bench repeatability
Recommended Use: For detection of non-volatile and semi-volatile sample components.
Features Header
Quantification for your entire sample
Finding the right balance in a detector designed for evaporative light scattering detection can be the difference between good sensitivity of semi-volatile components and high peak dispersion. The 2424 ELS Detector was designed with this critical balance in mind and delivers reproducible quantification for semi-volatile components without adding high dispersion to fast LC separations. Sample components that elute in the column void volume can be difficult to detect with many techniques, creating an issue of particular concern for strong UV absorbing diluents such as dimethyl sulfoxide (DMSO). The desolvation characteristics of the 2424 ELS Detector can remove the sample diluent interference to give visibility to unretained components in your sample.
Complex applications with gradient analysis
Whether trying to monitor a complex process such as the consistent production of food oils or verifying their authenticity to prevent adulteration, the use of gradient analysis is important for providing a wider separation range of your samples. The 2424 ELS Detector is entirely compatible with gradient analysis, and with significantly reduced stabilization times as compared to other ELS detectors, you can get consistent answers, faster.
Enhance your existing detection capabilities
For applications where not all components have a UV chromophore, adding ELS detection expands the visibility of your sample by providing a complementary detection capability. The 2424 ELS Detector offers reference energy monitoring for consistent long-term signal, 60 degrees scatter angle detection to minimize stray light and optics polarization and long-term optimal sensitivity, and normalized energy output for improved bench-to-bench repeatability.
Boost confidence in results with a complete chromatographic picture
Pair a 2424 ELS Detector with a Waters 2489 UV/Vis Detector and SQ Detector 2 single quadrupole mass detector, and achieve the capability to:
- Derive more complete peak information in one chromatographic run.
- Detect molecules that lack a UV/Vis chromophore, complementing absorbance detector information.
- Analyze compounds that don’t ionize well by mass spectrometry (MS).
Select the right chromatographic data system for your laboratory’s needs from Empower or MassLynx software. The 2424 ELS Detector is also compliance-ready as part of a Waters LC system – all supported within the Systems Qualification Tool (SystemsQT) technology.
