XSelect Premier Columns
Maximize selectivity with problem-solving technologies for a wide range of analytes
Get the best injection to injection reproducibility in your chromatographic separations with Waters XSelect Premier 2.5 µm and 3.5 µm Columns, which utilize MaxPeak High Performance Surfaces (HPS) Technology. Ideal for the wide range of analytes encountered in method development, XSelect Premier Columns combine modern particle technologies and ligands with the protection of MaxPeak HPS Technology.
Designed to maximize selectivity, XSelect Premier Columns are built on one of two innovative base particle technologies, Charged Surface Hybrid (CSH) and High Strength Silica (HSS). The integration of MaxPeak HPS allows you to achieve balanced, controlled interactions between your analytes, mobile phase, and the analytical column for the highest performance chromatographic separations.
XSelect Premier Columns
Waters offers a wide selection of XSelect Column chemistries.
Specifications
Overview
- Reduces column conditioning and passivation for higher productivity
- Maximizes selectivity with excellent stability at low pH
- Improves sensitivity and peak shape for basic compounds
- Increases reproducibility from analysis to analysis, for more confidence in analytical results
- Prolongs column lifetimes with optional VanGuard FIT format
Recommended Use: For improving selectivity, peak shape, and retentivity in method development.
XSelect Premier Column Featured Technologies
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Reduce analyte/surface interactions -
Increase analyte recovery
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Better peak shape
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Increase sensitivity
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All-in-one guard, plus column design
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Achieve longer column lifetimes
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Easy installation
* Specific to columns noted with VanGuard FIT
XSelect Premier CSH Column Characteristics
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Alternative selectivity to existing C18 columns
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Low anion exchange
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General purpose hybrid columns
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Improved peak shape for bases with low pH mobile phase
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Reduction in analyte/surface interactions
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Excellent pH stability
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VanGuard FIT column option
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Alternative selectivity for aromatic compounds
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Medium anion exchange
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General purpose hybrid columns
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Improved peak shape for bases with low pH mobile phase
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Reduction in analyte/surface interactions
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Excellent pH stability
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VanGuard FIT column option
XSelect Premier HSS Column Characteristics
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Excellent reversed-phase retention for polar analytes
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100% water wettable
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General purpose silica columns
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High retention
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Reduction in analyte/surface interactions
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Excellent low pH stability
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VanGuard FIT column option
XSelect Premier HPLC and UHPLC Application-Specific Column Characteristics
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Outstanding peak capacities with formic acid for MS-based applications
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Excellent performance with TFA for optical based applications
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Less dependence on TFA or FA to achieve optimal peak capacity
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Accepts greater peptide mass loads than many competitive technologies for detection of low-level impurities
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At low pH with the positive charge on CSH, you get less secondary interactions with the particle
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Superior peak shape and reduced tailing for acidic peptides
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Enhanced recovery and sensitivity for acidic peptides
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Separations that require silica-based selectivity
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Separations that necessitate increased peptide retention
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Ideally suited for small, hydrophilic peptides
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Superior peak shape and reduced tailing for acidic peptides
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Enhanced recovery and sensitivity for acidic peptides
The selectivity you need for method development
Maximize selectivity while minimizing variability with Waters XSelect Premier Columns, which provide the chemistries to enhance selectivity for method development while preventing unwanted analyte-surface interactions that can cause variability.
Two base particles, HSS and CSH, provide enhanced selectivity for acidic, basic, and neutral compounds across a wide pH range. For formic acid mobile phases, XSelect Premier CSH C18 Columns are the first choice for method development. You can enhance selectivity for aromatic compounds with XSelect Premier Phenyl-Hexyl Columns. Finally, increase retention for polar compounds under reversed-phase LC conditions with XSelect Premier HSS T3 Columns, which are compatible with 100% aqueous mobile phases.
The results you want. None of the interactions you don’t.
When developing analytical methods, having the confidence that analytes will not interact with metal ions in the flow path is critical. Analyte/surface interactions can lead to poor peak shape, analyte loss/misidentification, and ultimately costly sample re-work. The MaxPeak HPS Technology found in Waters XSelect Premier Columns significantly reduces unwanted analyte/surface interactions, so you can be sure you’re seeing everything in your sample --from the first injection on.
Stay compliant with smart column options
Ideal for compliant laboratories, smart column options are available for identifying and tracking column information. The eCord is a data recording device which is permanently attached to the column body of 2.x μm particle size (2.1 and 3.0 mm internal diameter) and ACQUITY UPLC columns and is standard for those column offerings. Rather, the eConnect column tag is a permanently attached electronic tag device for HPLC columns (≥ 2.x μm particles) used with Alliance iS and Alliance iS Bio HPLC Systems that are optional. Data from column devices (eCord device or eConnect column tag) can be accessed using the respective system’s console. These smart-column abilities provide a quick overview of column history and can be utilized as a basic troubleshooting tool. Data residing on these devices are automatically imported by and later searchable via Empower CDS.
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