Xevo TQ Absolute Triple Quadrupole Mass Spectrometer
Absolute power to easily quantitate your most challenging compounds
Achieve absolute confidence to reach lower limits of quantitation even for challenging negative ionizing compounds with an instrument that delivers absolute performance – the Xevo TQ Absolute.
An incredibly compact, more sustainable tandem quadrupole mass spectrometer, the Waters Xevo TQ Absolute enables your lab to achieve and maintain high performance and productivity. With Xevo’s consistent robustness, the Xevo TQ Absolute now enables you to quantify those challenging small mass, negative ionizing compounds with absolute sensitivity and confidence. All with the reassurance your ESG commitments are being considered.
Xevo TQ Absolute Triple Quadrupole Mass Spectrometer
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Specifications
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API sources and ionization modes |
High performance ZSpray dual-orthogonal API sources: 1) Multi-mode source – tool free ESI/APCI/ESCi* (standard) NB – Dedicated APCI requires an additional probe (optional) 2) UniSpray ion source (optional) 3) Tool-free APCI probe (optional) 4) nanoFlow™ ESI source* (optional) 5) ASAP* (optional) 6) APGC ion source* (optional) Optimized gas flow dynamics for efficient ESI desolvation Tool-free source exchange Vacuum isolation valve Tool-free access to user serviceable elements Plug-and-play probes De-clustering cone gas Software control of gas flows and heating elements |
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UniSpray ion source option |
UniSpray is an ionization technique designed to broaden the scope of compounds which can be analyzed in a single run, including those which typically optimize in ESI, APCI or APPI. Enhanced ionization efficiency and desolvation allow the potential to combine several methodologies into one, or simply enable the operator to keep the same source for multiple methods, requiring less time performing set-up and routine maintenance, and more time delivering results |
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Ion source transfer optics |
StepWave XS ion transfer optics delivering class leading UPLC™-MS/MS sensitivity. The unique off-axis design and segmented quadrupole second stage dramatically increases the efficiency of ion transfer from the ion source to the quadrupole MS analyzer at the same time as actively eliminating undesirable neutral contaminants |
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Mass analyzer |
Two high-resolution, high-stability quadrupole analyzers (MS1/MS2), plus pre-filters to maximize resolution and transmission while preventing contamination of the main analyzers |
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Collision cell |
T-Wave enabled for optimal MS/MS performance at high data acquisition rates; Software programmable gas control |
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Detector |
Low-noise, off-axis, long-life photomultiplier XDR Detector |
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Vacuum system |
One splitflow turbomolecular pump One vacuum backing pump |
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Dimensions |
Width: 43.0 cm (16.9 in.) Height: 79.0 (31.1 in) Depth: 96.0 (37.8 in) |
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Regulatory approvals/marks |
CE, CB, NRTL (CAN/US), RCM |
* Not available with waters_connect.
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Software |
Systems supported on waters_connect and MassLynx version 4.2 or later |
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System setup and method development |
System parameter checks and alerts Integrated sample/calibrant delivery system + programmable divert valve Automated mass calibration Automated sample tuning Automated MRM method development UPLC-MS/MS System Check – on-column performance test |
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Automated MRM scheduling (acquisition rate assignment) |
Dwell time, inter-channel delay time and inter-scan delay time for individual channels in a Multiple MRM experiment can be automatically assigned (using the Auto-Dwell feature) to ensure that the optimal number of MRM data points per chromatographic peak are acquired. The Auto-Dwell feature dynamically optimizes MRM cycle times to accommodate retention time windows that overlap. This greatly simplifies MRM method creation, irrespective of the number of compounds in a single assay, while at the same time ensuring the very best quantitative performance for every experiment |
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waters_connect Software |
The waters_connect Software provides a modern user experience with a HUB design and apps that provide a consistent connected user experience across all applications. It is built for applications with convenient access to scientific apps allowing accelerated time-to-results and result quality. There are common utilities that complete the end-to-end workflow and help increase productivity and efficiency. Confidently report results with accurate, reliable, regulation-standard data from application-focused quantitative workflows with built in traceability for utmost integrity. |
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Acquisition modes |
Full scan MS Product ion scan Precursor ion scan Constant neutral loss scan Multiple reaction monitoring (MRM) Simultaneous Full scan and MRM (RADAR) |
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RADAR |
An information rich acquisition approach that allows you to collect highly specific quantitative data for target compounds while providing the ability to visualize all other components |
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Mass range |
2 to 2048 m/z |
Compare Xevo TQ Systems
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Xevo TQ-S cronosXevo TQ-S cronos
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Xevo TQ-S microXevo TQ-S micro
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Xevo TQ-XSXevo TQ-XS
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Xevo TQ AbsoluteXevo TQ Absolute
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|---|---|---|---|---|
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Dimensions (w x h x d) |
Dimensions (w x h x d) |
Dimensions (w x h x d) |
Dimensions (w x h x d) |
Dimensions (w x h x d) |
|
Dimensions (w x h x d) |
35.6 x 60 x 93 cm |
35.6 x 60 x 93 cm |
61 x 70.7 x 99.5 cm |
43 x 79 x 96 cm |
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Sensitivity key |
Sensitivity key |
Sensitivity key |
Sensitivity key |
Sensitivity key |
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Sensitivity key |
★★ |
★★★ |
★★★★ |
★★★★★ |
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Mass range |
Mass range |
Mass range |
Mass range |
Mass range |
|
Mass range |
2 to 2048 m/z |
2 to 2048 m/z |
2 to 2048 m/z |
2 to 2048 m/z |
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Chromatographic configuration compatibility |
Chromatographic configuration compatibility |
Chromatographic configuration compatibility |
Chromatographic configuration compatibility |
Chromatographic configuration compatibility |
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Chromatographic configuration compatibility |
ACQUITY Arc* ACQUITY Premier ACQUITY UPC2* ACQUITY UPLC ACQUITY UPLC M-Class* |
ACQUITY Premier ACQUITY UPC2* ACQUITY UPLC ACQUITY UPLC M-Class* APGC* |
ACQUITY Premier ACQUITY UPC2* ACQUITY UPLC ACQUITY UPLC M-Class* APGC* |
ACQUITY Premier ACQUITY UPLC ACQUITY UPLC M-Class* APGC* |
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Ion sources compatibility |
Ion sources compatibility |
Ion sources compatibility |
Ion sources compatibility |
Ion sources compatibility |
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Ion sources compatibility |
APCI ASAP* ESCi* ESI |
APCI APGC* ASAP* ESCi* ESI ionKey* Nanoflow* |
APCI APGC* ASAP* ESCi* ESI ionKey* Nanoflow* |
APCI APGC* ASAP* ESCi* ESI Nanoflow* |
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Acquisition modes |
Acquisition modes |
Acquisition modes |
Acquisition modes |
Acquisition modes |
|
Acquisition modes |
Full scan Product scan Precursor ion scan Constant neutral loss scan Multiple reaction monitoring (MRM) Simultaneous Full Scan and MRM (RADAR) |
Full scan Product scan Precursor ion scan Constant neutral loss scan Multiple reaction monitoring (MRM) Simultaneous Full Scan and MRM (RADAR) |
Full scan Product scan Precursor ion scan Constant neutral loss scan Multiple reaction monitoring (MRM) Simultaneous Full Scan and MRM (RADAR) |
Full scan Product scan Precursor ion scan Constant neutral loss scan Multiple reaction monitoring (MRM) Simultaneous Full Scan and MRM (RADAR) |
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Detector ** |
Detector ** |
Detector ** |
Detector ** |
Detector ** |
|
Detector ** |
Low noise, off axis, long life photomultiplier** |
Low noise, off axis, long life photomultiplier** |
Low noise, off axis, long life photomultiplier** |
Low noise, off axis, long life photomultiplier** |
|
Ion source transfer optics |
Ion source transfer optics |
Ion source transfer optics |
Ion source transfer optics |
Ion source transfer optics |
|
Ion source transfer optics |
StepWave XS |
StepWave XS |
||
|
MRM speed |
MRM speed |
MRM speed |
MRM speed |
MRM speed |
|
MRM speed |
555 MRM/ sec |
555 MRM/ sec |
500 MRM/ sec |
500 MRM/ sec |
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Regulatory approval *** |
Regulatory approval *** |
Regulatory approval *** |
Regulatory approval *** |
Regulatory approval *** |
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Regulatory approval *** |
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Third party software interfaces |
Third party software interfaces |
Third party software interfaces |
Third party software interfaces |
Third party software interfaces |
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Third party software interfaces |
LIMS interface MassLynx SkyLine interface |
LIMS interface MassLynx SkyLine interface |
LIMS interface MassLynx SkyLine interface |
LIMS interface MassLynx SkyLine interface |
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MassLynx security |
MassLynx security |
MassLynx security |
MassLynx security |
MassLynx security |
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MassLynx security |
Yes |
Yes |
Yes |
Yes |
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Software options |
Software options |
Software options |
Software options |
Software options |
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Software options |
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* Not available with waters_connect
** Less than 1% of Waters’ tandem quadrupole mass spectrometers require a detector replacement on an annual basis. [Source: Waters’ internal data on the service history of its tandem quadrupole mass spectrometers launched between 2006 and 2022]
*** Regulated approval marks include CE, CB, NRTL (Canada/USA), RCM
Overview
- Absolute performance: Achieve lower limits of quantitation to meet regulatory requirements with up to 15x more sensitivity for challenging negative ionizing compounds than the previous product.
- Absolute efficiency: Achieve improved environmental sustainability and lower your laboratory operational costs with an instrument that uses approximately 50% less electricity and gas and produces 50% less heat than most other high performance TQ mass spectrometry instruments on the market.
- Absolute confidence: Ensure consistent robustness and reproducibility so you can maintain performance and productivity over a longer time period.
- Absolute productivity: Boost your productivity with flexible software solutions, including waters_connect, the modern, intuitive informatics platform that can save up to 50% of your data review time, while facilitating data integrity.
Recommended Use: Reach lower limits of quantitation and meet regulatory requirements, even for challenging negative ionizing compounds.
Features Header
Achieve absolute performance with improved sensitivity
To reach lower limits of quantitation and meet regulatory requirements, even for challenging negative ionizing compounds, you need an instrument that delivers absolute performance. Xevo TQ Absolute delivers up to 15x better sensitivity for challenging negative ionizing compounds than the previous product, so you can make confident decisions, fast.
Improve sustainability and lower operational costs
Many businesses are trying to actively address environmental sustainability while also reducing operational costs. The Xevo TQ Absolute makes it possible to do just that. The Xevo TQ Absolute was developed to achieve lower electricity consumption, gas consumption, and BTU/hr output - lessening the need for air conditioning and lowering costs. The Xevo TQ Absolute also provides more analytical capability per square foot of lab space by minimizing the LC-MS/MS footprint, so laboratory managers can fully optimize their facilities and increase efficiency.
Waters Xevo TQ Absolute**
Relative Bench Width
100%
Power Consumption
1460W
Air Conditioning Demand (Heat Displacement)
4,980 Btu/h
Nitrogen/Zero-Grade Air Consumption
23 L/min
Audible Noise
59.2 dB
SCIEX™ 7500*
Relative Bench Width
184%
Power Consumption
3077W
Air Conditioning Demand (Heat Displacement)
10,500 Btu/h
Nitrogen/Zero-Grade Air Consumption
52 L/min
Audible Noise
68 dB
*Source: Accessed January 2022 related to document RUO-IDV-01-9809-G SCIEX Triple Quad 7500 LC-MS/MS System - QTRAP Ready Site Planning Guide
**Source: Xevo TQ Absolute Site Preparation Guide, power consumption range mid-point of 960 W + Ebara rough pump 500 W
Ensure absolute productivity with flexible software options
Achieve the ultimate flexibility to choose the right solution for your lab with our flexible software options for quantitation - the waters_connect and MassLynx software platforms. Our modern, app-based software platform waters_connect delivers efficiency and usability benefits, including the unique Exception Focused Review (XFR) functionality that can save up to 50% of your data review time and ensures your lab is as productive as possible. Meanwhile, our tried, well-established MassLynx Software package delivers superior versatility and flexibility across all application areas.
Maintain peak performance longer with robustness and reproducibility
Analytical laboratories face a number of evolving challenges, so absolute confidence that your analytical instrumentation can keep pace is critical. The Xevo TQ Absolute has been specifically developed to deliver consistent robustness and reproducibility to maintain performance and productivity over a longer time period. Achieve the best performance while minimizing contamination and reducing the need for inconvenient downtime to clean the instrument with the Xevo TQ Absolute’s optimal probe positioning guidance. Your lab can also maximize uptime by minimizing contamination of the source from sample matrix or mobile phase salts with the Xevo TQ Absolute’s new source shield.
Accelerating your success with award winning service
Ensure your laboratory runs efficiently and is ready to address the opportunities of tomorrow with Waters comprehensive analytical solutions with expert training (APS) and flexible and cost-effective solutions to advance your business with system service (FlexCHOICE), trade-ins and technological upgrades (FlexUP).
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