Potency Testing and Cannabinoid Profiling

Potency Testing and Cannabinoid Profiling

Achieve fast and flexible potency testing and cannabinoid profiling with the Waters Cannabinoid Analyzer Solution, a comprehensive package for accurate product labeling, tracking extraction efficiency, and product formulation. With Waters, your testing lab can achieve reliable results with a rapid ROI.

Achieve fast and flexible potency testing and cannabinoid profiling with the Waters Cannabinoid Analyzer Solution, a comprehensive package for accurate product labeling, tracking extraction efficiency, and product formulation. With Waters, your testing lab can achieve reliable results with a rapid ROI.
Achieve the fastest run times, maximum chromatographic resolution, and lowest solvent usage for potency testing and cannabinoid profiling with Waters Cannabinoid Analyzer Solution.
Achieve the fastest run times, maximum chromatographic resolution, and lowest solvent usage for potency testing and cannabinoid profiling with Waters Cannabinoid Analyzer Solution.

Overview

Potency testing is the most frequently run assay in the cannabis and hemp industries for profiling main and emerging cannabinoids of interest. Critical for compliance with state and federal regulations, potency testing and cannabinoid profiling is also used for accurate product labeling, tracking extraction efficiency, and product formulation.

Waters potency testing and cannabinoid profiling solution is a comprehensive package that utilizes ultra performance liquid chromatography (UPLC) technology for fastest run times, maximum chromatographic resolution, and lowest solvent usage. For those who need answers fast and a rapid return on investment, the Waters Cannabinoid Analyzer Solution includes:

Applications

Potency testing and cannabinoid profiling is important for compliance with state and federal regulations, accurate product labeling, tracking extraction efficiency, and product formulation. Learn more about potency testing and cannabinoid profiling with these application notes.

Potency testing and cannabinoid profiling is important for compliance with state and federal regulations, accurate product labeling, tracking extraction efficiency, and product formulation. Learn more about potency testing and cannabinoid profiling with these application notes.

Application Notes

Webinar: Analytical Tools for Characterizing Cannabinoids for Quality, Safety, and Research Purposes

Learn from our webinar how you can identify what is in your cannabis product with liquid chromatography with HRMS and IMS or how much of it is there with targeted analyses through liquid chromatography with UV and MS.

Learn from our webinar how you can identify what is in your cannabis product with liquid chromatography with HRMS and IMS or how much of it is there with targeted analyses through liquid chromatography with UV and MS.
Watch webinar
Cannabis plant and laboratory scientific research

Solutions

Streamline your analysis and accelerate sample throughput with system solutions tailored to the needs of cannabis testing labs.

Streamline your analysis and accelerate sample throughput with system solutions tailored to the needs of cannabis testing labs.

Performance that advances your lab

Performance that advances your lab
ACQUITY UPLC H-Class PLUS System

Get the flexibility of quaternary or binary solvent blending and decrease your time to result with the ACQUITY UPLC H-Class PLUS System to improve the characterization of your most complex samples.

  • Potency Testing and Cannabinoid Profiling

Separate beyond question with the power of mass detection

Separate beyond question with the power of mass detection
ACQUITY QDa II Mass Detector

Minimize the risk of unexpected coelutions, confirm analyte identification, and enhance the analytical value of each analysis using the ACQUITY QDa II Mass Detector.

  • Potency Testing and Cannabinoid Profiling

The ease of reversed-phase meets the power of normal-phase

The ease of reversed-phase meets the power of normal-phase
ACQUITY UPC2 System

Address routine and complex separation challenges while delivering the reliability, robustness, sensitivity, and increased throughput of convergence chromatography techniques with ACQUITY UPC2 System.

  • Potency Testing and Cannabinoid Profiling

Highly reliable, low complexity, accurate routine analysis for all

Highly reliable, low complexity, accurate routine analysis for all
Arc HPLC System

Obtain high-efficiency separations and quality data to meet your testing requirements with Arc HPLC System and easily improve the performance of your existing LC methods without compromising data quality in your analysis.

  • Potency Testing and Cannabinoid Profiling

The future of quantitation is here

The future of quantitation is here
waters_connect for Quantitation

Reduce time spent on data review and process large sample batches more quickly and easily with waters_connect for Quantitation, ideal for LC pesticide and mycotoxin testing for cannabis and hemp.

  • Potency Testing and Cannabinoid Profiling

Faster, cleaner sample preparation for cannabis and hemp

Faster, cleaner sample preparation for cannabis and hemp
Oasis Sample Extraction Products

Achieve unmatched purity, consistency, and quality for pesticide analysis in cannabis and hemp with Oasis Sample Extraction Products, including Oasis PRiME HLB products, which set the performance standard for solid phase extraction cleanup in routine analysis.

  • Potency Testing and Cannabinoid Profiling

Maintain peak system performance, minimize downtime, address application challenges, and support compliance requirements with services and support from Waters.

Maintain peak system performance, minimize downtime, address application challenges, and support compliance requirements with services and support from Waters.

Optimize productivity in your laboratory

Optimize productivity in your laboratory
Instrument Services

Maintain peak instrument performance, minimize downtime, address your cannabis and hemp application challenges, and ensure your instruments are up to date with the Waters suite of instrument services.

  • Potency Testing and Cannabinoid Profiling

Make science more accessible with Waters Capital

Make science more accessible with Waters Capital
Payment Solutions

Minimize the risk of unexpected coelutions, and confirm analyte ID, and enhance the analytical value of each analysis using the ACQUITY QDa Mass Detector.

  • Potency Testing and Cannabinoid Profiling

The data speaks for itself

The data speaks for itself
Calibration curves for 18 cannabinoids at 228 nm and individual SIR channels from 0.1–50 µg/mL.
UPC2 chromatograms showing (1) separation of the THC isomer standards, (2) analysis of CBD oil after being heated in an oven overnight at 55 °C, (3) analysis of CBD oil after being exposed to acidic conditions and heating overnight at 55 °C, and (4) analysis of untreated CBD oil (control). THC isomers that were identified in the CBD samples are indicated. The separations were achieved at 2 mL/min and 10% ethanol on the AMY1 column using 1 µL injections.
Figure A (top) - PDA chromatogram of an authentic standard mix of 8 isomeric cannabinoids at 228 nm (top) (100 mg/mL, 0.5 mL), and (beneath) Δ8-THC distillate sample A (1 mg/mL, 0.5 mL). Three components can be identified in the sample based on tR; Figure B (bottom) - PDA chromatogram at 228 nm (top) showing expanded view of UV baseline and the MS BPI (beneath).
Chromatograms from the analysis of a high Δ9-THC variety flower sample analyzed using UV at 228 nm and SIR of m/z 315 and m/z 357. MS analysis increases the confidence in the identification of Δ9-THC in the sample.

Webinars and Resources

  • Brochure

Cannabis and Hemp — Quality and Safety Testing Brochure

Cannabis and Hemp — Quality and Safety Testing Brochure
Download
  • Brochure

Sample Preparation and Chemistry Products for Cannabis Quality and Safety Applications

Sample Preparation and Chemistry Products for Cannabis Quality and Safety Applications
Download
  • Case Study

Building Laboratory Capacity to Ensure Cannabis Safety, Quality, and Efficacy

Building Laboratory Capacity to Ensure Cannabis Safety, Quality, and Efficacy
Download

Related

Cannabis and Hemp Testing
Ensure you meet cannabis and hemp regulatory compliance requirements while enabling growth and innovation with Waters quality and safety testing laboratory solutions.

Learn more about Potency Testing and Cannabinoid Profiling Solutions.

Learn more about Potency Testing and Cannabinoid Profiling Solutions.
Achieve the fastest run times, maximum chromatographic resolution, and lowest solvent usage for potency testing and cannabinoid profiling with Waters Cannabinoid Analyzer Solution.
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