ACQUITY UPLC Refractive Index Detector
Universal detection for your non-UV analytes
Improving resolution and throughput for your isocratic applications, such as advanced polymer chromatography (APC), food QC applications, pharmaceutical USP methods, and industrial process monitoring, is a priority.
The ACQUITY UPLC Refractive Index (RI) Detector offers unparalleled performance for the isocratic UHPLC/UPLC analysis of analytes without a UV chromophore. Its low-dispersion fluidics are designed to match the performance needed for narrow UPLC peaks while still delivering stable baseline performance, low noise, and a wide, linear dynamic range.
ACQUITY UPLC Refractive Index Detector
Specifications
|
Refractive index range |
1.00 to 1.75 |
|
Measurement range |
7.0 x 10-9 RIU to 5.0 x 10-4 RIU |
|
Linear dynamic range |
≤5.0% over ±5.0 x 10-4 RIU |
|
Noise |
≤±1.5 x 10-9 RIU (2 points/s, 1 s filter time constant 0.5 mL/min, 100% H2O) |
|
Drift |
≤2.0 x 10-7 RIU/h (2 points/s, 1 s filter time constant, 0.5 mL/min, 100% H2O) |
|
Sampling rates |
1 to 80 points/s |
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Filter time constant |
0.0 to 5.0 s (Independently optimized) |
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Compatible flow rate range |
0.05 to 2.00 mL/min |
|
RIU full scale settings |
1 to 500 x 10-6 RIU |
|
Flow cell design |
Fused quartz |
|
Light source |
LED 870 nm |
|
Flow cell volume |
1.3 μL |
|
Internal fluidic volume |
<15 μL |
|
Wetted materials |
316 stainless-steel, fluoroelastomer, fluoropolymer, Natural PPS, fused silica, and PEEK (for non-APC systems) |
|
Pressure limit |
≤145 psi Flow Cell Options |
|
Physical specifications |
Width: 34.3 cm (13.5 inches) Height: 20.8 cm (8.2 inches) Depth: 61.0 cm (24.0 inches) |
Overview
- Carry out universal detection of analytes without a UV chromophore that are separated by isocratic analysis
- Benefit from complete compatibility with a wide range of challenging solvents
- Achieve low-dispersion characteristics for the narrow peaks produced by ACQUITY UPLC PLUS series and ACQUITY APC systems
- Obtain low baseline drift due to a thermally isolated optics bench and highly efficient temperature equilibration of the incoming eluent
Recommended Use: For achieving unparalleled performance of isocratic UPLC or APC analysis of samples without a UV chromophore.
Features Header
Get faster answers for your quality control applications
Laboratories around the world have deployed UPLC technology to improve data quality and throughput by reducing analysis run times and increasing chromatographic resolution, making integration and quantification easier and more reliable. With the ACQUITY UPLC Refractive Index Detector, these same benefits can now be realized for samples with analytes that require RI detection due to the absence of a UV-chromophore.
Low dispersion detection – a key component for APC
The ACQUITY APC System defines a new category of chromatographic polymer analysis that gives you more information about your polymers, faster than ever before. Combining low-dispersion system fluidics with rigid, small particle columns of a wide range of pore sizes, the system defines the ultimate in polymer peak resolution, particularly for low molecular weight oligomers.
Simplify method transfer and uplevel your HPLC/RI methods
The benefits of transferring your existing HPLC methods to UPLC/UHPLC have been demonstrated time and time again, across multiple application types. Now, HPLC methods that require refractive index detection can also be seamlessly transferred to UPLC. Intuitive tools, including the ACQUITY UPLC Columns Calculator and the Reversed-Phase Column Selectivity Chart, are available to help you select the right UPLC stationary phase and scale your existing HPLC/RI methods to your UPLC/RI system efficiently and easily.
Innovative technology for the chromatographic laboratory
The ACQUITY UPLC RI Detector’s innovative flow cell design addresses challenges of technical and environmental hurdles found when running an RI analysis. Coupled with a high energy LED, which delivers exceptional energy transmittance through the flow cell, the detector delivers maximum sensitivity while maintaining excellent peak shape. The integrated solvent valves provide automatic reference cell purging capabilities to maintain optimal baseline performance and solvent recycling, efficiently reducing costly solvent consumption.
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