Xevo TQ-GC Mass Spectrometry System
The perfect addition to your laboratory
Demands to meet regulations are increasing pressure on laboratories, and in order to meet these challenges laboratories must develop and run methods that provide high-quality, consistent results, day in and day out.
The Xevo TQ-GC is a robust Electron Ionization (EI) and Chemical Ionization (CI) Gas Chromatography (GC)-MS/MS platform that allows routine quantification of multiple contaminants in complex matrices. The Xevo TQ-GC consistently surpasses the sensitivity required to meet regulatory limits, thus reducing the need for frequent user intervention and re-optimization. In addition, MassLynx Software security controls user access, giving you more control to assist with laboratory compliance.
Laboratories can also develop methods rapidly using Quanpedia, which allows fast response to changes in legislative demands and for customized methods. All the speed, sensitivity, and reliability you have come to expect from Xevo now with GC-MS/MS.
Xevo TQ-GC Mass Spectrometry System
Specifications
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Ionization sources |
EI standard, CI optional Tool free EI to CI and tool free ion source change for cleaning |
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User centric source design |
Easily assembled source designed to be tolerant for complex matrices Rapid source chamber removal and ionization mode change One-click complete system shutdown for any routine maintenance User changeable internal calibrant Source temperature limited to 250 °C to avoid excess fragmentation while retaining high chromatographic performance |
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EI filaments |
Dual EI Yttrium-coated long-lasting filaments |
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Electron energy |
Range 10–200 eV |
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Pump down time |
Can pump down cold, vented instrument to working pressure (3e⁻⁵ mBar) and get to temperatures (250 °C source and 350 °C transfer line) in 15 minutes |
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Ion Source Transfer Optics |
Innovative user-centred design and are only able to be assembled one way, reducing training time and errors in re-assembly |
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Mass analyzer |
Two high resolution, high stability quadrupole analyzers (MS1/MS2), plus pre-filters to maximize resolution and transmission while preventing contamination of the main analyzers |
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Collision cell |
Innovative curved T-Wave which blocks meta-stable helium ions and neutral molecules reducing baseline noise. The T-Wave collision cell is assigned for optimal MS/MS performance at high data acquisition rates, with a minimal performance loss |
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Detector |
Low noise, off axis, long life photomultiplier detector |
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Vacuum system |
One split-flow air-cooled vacuum turbomolecular pump evacuating the source and analyzer; one vacuum backing pump |
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Dimensions |
Width: 97.0 cm (38.2 in), inclusive of GC and MS Height: 59.3 cm (23.3 in) Depth: 91.3 cm (36.0 in) |
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Regulatory approvals/marks |
CE and NRTL |
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Software |
Systems supported on MassLynx version 4.2; TargetLynx XS Application Manager is included as standard |
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IntelliStart Technology |
This system is designed to be easily accessible and will automatically perform source tuning, mass resolution, and calibration from a reference compound. In addition there are multiple system health checks for temperatures, filament settings, peak shapes, peak resolutions, peak positions, peak ratios, and instrument vacuum |
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Quantification methods database |
Quanpedia – a database for storing and sharing user defined GC/MRM acquisition methods and associated processing methods for the targeted quantification of named compounds is provided as standard; database entries for a number of applications are also provided as standard |
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Automated MRM scheduling (acquisition rate assignment) |
Dwell time, inter-channel delay time, and inter-scan delay time for individual channels in a multiple MRM experiment can be automatically assigned (using the Auto-Dwell feature) to ensure that the optimal number of MRM data points per chromatographic peak is acquired. The Auto-Dwell feature can dynamically optimize MRM cycle times to accommodate retention time windows that either partially or completely overlap. This greatly simplifies MRM method creation, irrespective of the number of compounds in a single assay, while at the same time ensuring the very best quantitative performance for every experiment |
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Automated MRM scheduling (acquisition window assignment) |
Multiple MRM experiments can be scheduled (manually or automatically using the database) using retention time windows to optimize the cycle time for each MRM channel monitored. If required, MRM retention time windows can overlap partially or completely. This ensures that MRM data acquisition rates will be optimal for the quantification of all analytes in a given assay |
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Acquisition modes |
Full scan MS Product ion scan Precursor ion scan Selected ion recording (SIR) Multiple reaction monitoring (MRM) Simultaneous full scan and MRM (RADAR) |
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Product ion confirmation (PIC) mode |
MRM acquisition acts as an automatic trigger for the acquisition of product ion spectra |
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RADAR |
An information rich acquisition approach that allows you to collect highly specific quantitative data for target analysis while providing NIST-searchable full scan spectra in parallel |
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Mass range |
2–1250 m/z |
Overview
- Reduce training time and costs with a single software workflow for GC-MS/MS and LC-MS/MS analysis
- Achieve comprehensive application coverage powered by Quanpedia database driven workflow
- Easily surpass regulatory limits with fit-for-purpose performance in difficult matrices
- Choose from a wide range of injection modes, including liquid, headspace, and solid phase microextraction (SPME) analysis
- Control access to the GC-MS system to meet regulatory requirements with MassLynx security
- Simplify maintenance tasks with a rapid and mistake-proof source design
Recommended Use: For routine quantitation of multiple contaminants in an extracted matrix sample.
Features Header
Maximize uptime to ensure your success
Ensuring you achieve reliable and predictable results is at the heart of the design of the Xevo TQ-GC. The system has been rigorously tested to ensure that you spend less time on routine maintenance, and that it can be scheduled to fit around the laboratory workload, maximizing uptime and minimizing disruption.
To ensure you don’t spend your precious time on lengthy instrument setup, Intellistart health check informs you whether the system is ready to run injections and, if not, how the situation can be remedied. Your lab only needs minimal tools for instrument maintenance, and if any maintenance is needed, it is fast and mistake-proof.
Achieve efficiency and flexibility
In a busy analytical lab, time is precious, especially when demands change regularly and the requirement for shorter turnaround times is increasing. With Quanpedia, you can easily deal with a wide variety of sample matrices, target analytes and gas chromatography (GC) conditions. The fully customizable database means that you no longer need to be concerned about having the flexibility to adapt to changes in regulations, as it contains compound classes that are most relevant to regulations, and modifications to existing methods are quick and simple. You can reduce your method development time by including automatic scheduling of multiple reaction monitoring (MRM) transitions that account for any shift in retention times that occur because of column maintenance.
You can also shorten turnaround times by increasing the number of components in a single analytical run, which is enabled by acquisition rates of up to 500 MRM/sec with no significant degradation in performance. This means more MRM transitions can be added to a run while still achieving high quality results.
Capture the whole picture in targeted analyses
Reduce the risks to method performance and data quality associated with undetected interferences and unexpected compounds when conducting targeted analysis. RADAR improves method development and aids troubleshooting with the ability to detect and confirm analytes not specifically targeted through NIST library confirmation and routinely characterize unexpected contaminants. With this additional information, you can be completely confident in your data and avoid additional confirmatory analyses.
Confidently meet regulatory demands
To ensure confidence in results, most analysts would prefer to operate comfortably below regulatory limits. You can achieve this confidence with Xevo TQ-GC, not only through reliable high performance but also as a result of TargetLynx, an Application Manager common across Waters LC and GC platforms. This means it not only gives full analyte quantification, simplified review of results, and customizable reporting, but also provides a common platform between instrument types simplifying data processing and reducing time to results.
With Waters MassLynx Basic Security, you are in control. Ideal for laboratories who need to manage or control access to a GC-MS system. MassLynx Basic Security contains an events audit log for added traceability for audits and accreditation, and the security can also be used with TargetLynx acquisition software.
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