Sample Vials Through the Ages
From the 1700’s to the modern age, sample vials have been an integral part of the workflow in analytical laboratories. Today, we still test and certify the whole vial kit.
How Improved Selectivity in Immunosuppressant Analysis Can Help Organ Transplant Patients
The Waters MassTrak Immunosuppressant Calibrator, Control, and Internal Standard Sets, soon available, are developed to help laboratories utilize LC-MS/MS with confidence in their assay results.
BioAccord System with ACQUITY Premier: Some Things Work Better Together
Combining BioAccord, our most capable MS detection platform, with ACQUITY Premier UPLC, our highest performance LC system, to demonstrate superior performance.
The Quest for Maximum LC Performance: A Well-Packed Column Bed
As chromatographers seek maximum separation performance on their liquid chromatography (LC) systems, a key factor is the use of LC columns with an optimally packed column bed density. Solid-core columns manufactured with strict quality control for their packed bed density enable top efficiency, mechanical stability, and performance – no matter how tough your method conditions….
Comprehending COVID-19: How Consumables Can Increase LC-MS/MS Sensitivity
During 2020, we collaborated with many of our customers to develop targeted liquid chromatography–mass spectrometry/mass spectrometry (LC-MS/MS) methods to detect SARS-CoV-2 (the virus that causes COVID-19) from biological samples. However, the combination of the biological specimen, the sample collection medium, the viral load threshold, and the need for a high throughput method gave rise to…
Nuts About Christmas … And Mycotoxin Detection
A bowl of nuts, with polished or carved nutcrackers, is part of many traditional winter holiday feasts. Growing up in England in the 1970s, I enjoyed hazelnuts, almonds, walnuts and Brazil nuts as special treats for the Christmas holiday. Once I’d wrestled with a nutcracker, seemingly designed to send nuts and shards of shell across…
Tools for Chromatographic Success: Three Ways to Support Data Quality in Routine Analysis
Avoiding the pitfalls of data quality and integrity in the Pharma QC laboratory while running routine analyses is an ongoing challenge. Regulatory violations are frequently a result of a lack of complete data, suspect data, and improper audit trails. A recent report from Deloitte stated that data integrity violations account for over 70% of the…
Chords and Chemistry and the Benefits of Choosing Wisely
“A true measure of excellence for Waters is in orchestrating consistent instrument and chemistry optimization across applications, methods, and workflows.” I was on a job interview – more specifically, for my first position at Waters – where I was asked a compelling question. The question had to do with the consideration that Waters was a…
Bring efficiency back to your lab: How aging technology hinders ideal performance
In this series, we review considerations for keeping your lab at the forefront of science. As we adjust to living and working in a pandemic and anticipate future global and geopolitical events, Waters remains dedicated to supporting your business and unlocking the potential of your science. Our holistic separations solutions and expert support help you…
Choosing the Correct Column for Chromatographic Selectivity
When developing a method for the routine multiresidue analysis of pesticides in food commodities there are several factors that need to be considered when selecting which liquid chromatography (LC) column to use. The requirements include: Good retention for a range of physiochemical properties (polar, non-polar, base, acid). Moderate to high resolution (peak capacity). Sample extracts…
Change Up Your Routine (Analysis)
Enhancing performance, mitigating risk, and improving efficiency Today, Waters introduced the Arc HPLC, a modern liquid chromatography system that replicates established test methods while delivering improved performance. HPLC has been a cornerstone of routine analytical testing for decades. It has proven to be particularly important for quality control and manufacturing support laboratories in the pharmaceutical…
Mobile Phase Additives for Peptide Characterization
The characterization of peptides and proteins can be challenging due to issues such as adsorption, varying hydrophobicities, and specificity to name just a few. When analyzing peptides by Liquid Chromatography (LC) and Mass Spectrometry (MS), it’s beneficial to introduce mobile phase additives in order to facilitate ionization and enhance the analyte signal. Additionally, these additives…