Chances are that you or someone you know has been directly impacted by breast cancer. With 2,088,849 new cases and 626,679 deaths globally,1 it is the most frequently diagnosed cancer in women in most countries (154 of 185) and is the leading cause of cancer death in women in over 100 countries. Fortunately, significant strides…
Many years ago, I was hired by a biopharma company to develop analytical methods for therapeutic oligonucleotides. When a new colleague warned me about sample loss on LC columns I looked at him with skepticism. “Yes,” he insisted, “part of your DNA sample may be irreversibly bound to the column and you will never see…
In January of 2018, Waters kicked off its global Bioharmonization campaign with a blog post and video release, laying out a vision for how the Biopharmaceutical industry can achieve accelerated development and improved quality while enhancing productivity and lowering production costs. Central to this vision are “fit-for-purpose” analytical tools working together within a single compliance-ready…
After completing my undergraduate degree, I began work at the New England Newborn Screening Program (NENBS) in Jamaica Plain, Massachusetts. It wasn’t long before I realized the magnitude of the job I held in serving the public and my role in the life-saving tests that the program performed. The NENBS program consists of five testing…
What does “intelligence” mean in the context of biopharma analysis? Given the complex setting, much of the answer comes down to the task a user needs to complete, along with the question of who exactly that user is. In developing our BioAccord System, we wanted to expand the possibilities of high-resolution LC-MS analysis from characterization…
Newborn screening for inherited disorders has been heralded as one of the 10 greatest public health achievements of the first decade of the 21st century.1 The ability to pre-symptomatically identify newborn babies at risk of developing endocrine, hematologic, and metabolic disorders has dramatically improved or saved thousands of lives (and saved the healthcare system millions…
We’ve updated our UPLC systems to enable you to find faster, simpler, and better ways to do your work. Take a closer look at our new and improved ACQUITY UPLC PLUS Series.
From oligonucleotides and peptides to messenger RNA and CRISPR, ’tides are enjoying their time in the sun A year ago we wrote how oligonucleotide therapeutic development, which had seen a huge wave of investment in the late 1990s and early 2000s followed by a precipitous decline in the late 2000s, was once again on the…
What are the differences between micro-scale and conventional LC? Microflow (a.k.a. microscale) LC has been widely applied to proteomic research for years. Recently, as microflow LC-MS systems continue to evolve, more and more laboratories in various fields are weighing the implications of applying this small-is-beautiful technology. In this and my next two blog posts, I will discuss…