The Quest for Maximum LC Performance: A Well-Packed Column Bed

The Quest for Maximum LC Performance: A Well-Packed Column Bed

As chromatographers seek maximum separation performance on their liquid chromatography (LC) systems, a key factor is the use of LC columns with an optimally packed column bed density. Solid-core columns manufactured with strict quality control for their packed bed density enable top efficiency, mechanical stability, and performance – no matter how tough your method conditions….

Comprehending COVID-19: How Consumables Can Increase LC-MS/MS Sensitivity

Comprehending COVID-19: How Consumables Can Increase LC-MS/MS Sensitivity

During 2020, we collaborated with many of our customers to develop targeted liquid chromatography–mass spectrometry/mass spectrometry (LC-MS/MS) methods to detect SARS-CoV-2 (the virus that causes COVID-19) from biological samples. However, the combination of the biological specimen, the sample collection medium, the viral load threshold, and the need for a high throughput method gave rise to…

Oil: A Source of Light and Cause for Celebration

Oil: A Source of Light and Cause for Celebration

The use of light during holidays or festivals – in any form, including candles, lanterns, or fireworks – is significant, as we celebrate and look ahead to the future. Many friends and colleagues recently celebrated Diwali (where light represents the triumph of good over evil and light over darkness), and others begin Hanukkah, the Festival…

ACQUITY UPLC – 15 Years On and Still Going Strong

ACQUITY UPLC – 15 Years On and Still Going Strong

The 30th James L. Waters Annual Symposium  will take place on Monday, March 18 in Philadelphia as part of Pittcon 2019. The theme of this year’s Symposium focuses on early research efforts required to develop Ultra High Pressure Liquid Chromatography (UHPLC) and the impact that the adoption of this technology had on the analytical chemistry…

I Resolve to Get Better mAb Separations

I Resolve to Get Better mAb Separations

We listened and learned how scientists separate mAbs and ADCs; then we designed a novel column for LC-MS bioseparations A critical step toward the prolific and successful use of monoclonal antibodies (mAb) as biotherapeutics occurred in 1988 when techniques were introduced to humanize these biomolecules, eliminating or reducing the deleterious patient side effects that previous…