The Historical Role of Mass Spectrometry in Newborn Screening

The Historical Role of Mass Spectrometry in Newborn Screening

Newborn screening for inherited metabolic disorders dates to the early 1960s when Dr. Robert Guthrie in Buffalo, New York developed the first screening test for phenylketonuria (or PKU), a metabolic disease in which patients can’t metabolize the amino acid phenylalanine.

Why Tandem Mass Spec is Essential for Newborn Screening

Why Tandem Mass Spec is Essential for Newborn Screening

Mass spectrometry has been game changer in newborn screening because rather than having a single test for a single condition, there was now a technique that provided a single test for a large number of different conditions.

Advancing Omics Research and Reducing Bias with New MS Technology for Data-Independent Acquisition Experiments

Advancing Omics Research and Reducing Bias with New MS Technology for Data-Independent Acquisition Experiments

Targeted LC-MS based assays are increasingly applied in the post-discovery Omics area with an emphasis on validation, the first of many phases in translational research; and in studies that are aimed at gaining the understanding of biological systems in terms of drug development and treatment. Understanding the context of analytical results is driving current research,…

Phenome Network: A Harmonized Research Consortium for Innovative Global Health

Phenome Network: A Harmonized Research Consortium for Innovative Global Health

The world is facing an unprecedented convergence of environmental and lifestyle factors that dramatically increase our risk of chronic disease. Global warming, antimicrobial resistance, aging populations, and the prevalence of lifestyle-related illnesses are systematically affecting populations around the world and posing some of the greatest scientific and public health threats seen in modern times. These…

Do You See What We See? Mass Spectrometry Imaging is Revealing Insights in Biomedical Research

Do You See What We See? Mass Spectrometry Imaging is Revealing Insights in Biomedical Research

The spatial distribution of molecular species in a sample can provide a wealth of information about biological, chemical and physiological processes. Mass spectrometry (MS) imaging is a rapidly developing research technique that enables specific measurement of molecular targets at complex surfaces. This direct-from-sample analytical technique provides researchers with the information needed to quickly and objectively…