The Expanding Role of Mass Spec for Peptide Mapping in Multi-Attribute Monitoring Assays

There are two primary multi-attribute monitoring (MAM) assay choices for biologic development and QC: subunit protein mass analysis and peptide mapping by LC-MS. Here we explore how peptide mapping LC-MS MAM workflows are being used.

Webinar Highlights: Quantifying Cannabinoids in Oral Fluid to Determine Driving Impairment Following Marijuana Consumption

Q&A from a recent forensic toxicology webinar on using an ACQUITY UPLC I-Class/Xevo TQ-S micro MS system for quantifying cannabinoids in oral fluid.

Multi-Attribute Monitoring: The Expanding Role of Mass Spectrometry for mAb Subunit Analysis

Two MAM approaches for biotherapeutic analysis are being implemented today; one focused on the analysis of monoclonal antibody (mAb) subunits, and the other focused on the analysis of peptides from a protein digest (peptide mapping workflow). Both have their advantages and disadvantages. Here, we explore MAM for mAb subunit analysis.

From Characterization to Late Development, Manufacturing, and QC: The Expanding Role of Mass Spectrometry in Biotherapeutics

The improvements in LC-MS technology under GxP compliant-ready informatics for biopharmaceutical analysis has prepared the industry to expand the role of MS technologies beyond product characterization toward monitoring product and process quality attributes.

A Day in the Life of Dipesh Mistry, Principal Service, Support, and Development Engineer

Where does your service engineer turn if they need help? Meet Dipesh. He works in Waters’ Global Service Support (GSS) department in Wilmslow, UK. The team supports field service engineers, writes supporting documentation, and advises on service requirements for new products.

A Week in the Life of Vicky Starkie, Customer Success Team

Meet Vicky, who joined Waters’ Customer Success Team about two years ago with 20 years of LC-MS experience. She specializes in clinical forensic and toxicological applications supporting customers in Northern Europe.

Skin Lightening Products: Are They Cosmetics or Drugs?

You won’t like what we found when we tested skin lightening cosmetics that we purchased online.

A Week in the Life of Ian Davidson, LC-MS System Service Engineer

Meet Ian, an LC-MS system engineer based in the UK, who is responsible for system installs, service, and maintenance. Being a former Waters customer drives Ian’s approach to customer service and going the extra mile.

A Day in the Life of Michelle Wood, R&D Toxicology Manager, Scientific Operations

Michelle and her team are responsible for identifying high-demand assays and developing appropriate LC-MS solutions for use in toxicology.

A Week in the Life of Mark Halifax, Senior Analytical Scientist, Systems Evaluation

Have you ever wondered what’s required to design, build, and support an LC-MS system? Meet Mark, who works on our Systems Evaluation team.

Lake Fear?

Determining whether the cyanobacteria present in a water body are producing toxins requires laboratory testing. However, detection of microcystins is a challenging problem for water testing laboratories.

New Preparative Chromatography Learning Tool: Purification Primer

Chromatographers sometimes find themselves challenged as they move from analytical to preparative scales. To help gain a higher-level of understanding and knowledge of purification, check out our primer.